PREOPTIC AREA AND PHARMACOLOGIC SLEEP INDUCTION
PREOPTIC AREA AND PHARMACOLOGIC SLEEP INDUCTION
批准号:
6362823
负责人:
Paul R Vezina
金额:
$23.5万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-04-01 至 2004-02-29
中文摘要
描述(改编自申请人摘要):虽然大约20岁
英文摘要
DESCRIPTION (Adapted from applicant's abstract): Although approximately 20
million prescriptions for hypnotic medications are written each year, the
molecular mechanisms by which they act, and the neuroanatomic site(s) at
which they act. remain unclear. This problem is complicated by the wide
range of pharmacologic classes of compounds which induce sleep, and it is
uncertain whether these various agents differ in their mechanisms or site of
action. The investigator has begun to build a case that a common molecular
mechanism for several types of sleep-inducing compounds may involve
interaction with the benzodiazepine (BZ)-GABAa receptor complex. The
current proposal, based on the investigator's observations that
microinjection of pentobarbital or the BZ hypnotic triazolam into the medial
preoptic area (MPA) of the anterior hypothalamus induces sleep. addresses
the anatomical site(s) of action of sleep-inducing drugs. The goal is to
bring together these observations from the investigator's laboratory and
those from other laboratories indicating similar effects from
microinjections of ethanol and adenosine. The investigator shall explore
these observations further, addressing the following questions:
1. Do these findings hold when all these compounds are examined in the same
laboratory, under similar conditions, and do these various agents show clear
dose-responsiveness?
2. Are these effects specific to the BZ-GABAa recognition site?
3. Are these effects specific to the MPA, or do they occur with injection
into other structures?
4. Do they result as a consequence of altering hypothalamic temperature, or
by a more direct mechanism?
5. Is an intact MPA necessary for sleep induction by these agents when
given parenterally?
In a broader sense, the goal of this proposal it to move beyond the
conventional approach of simply identifying a hypnogenic compound, and
instead to develop a series of critical questions which should be asked
about any substance which alters sleep, including: 1) where does it act?;
2) on which receptors does it act?; 3) with which physiological processes
does it interact?; and 4) which brain sites are critical for its hypnogenic
effect? The investigator's goal, then, is both to characterize the
properties of four classes of hypnogenic substances, and to begin to build a
framework to make the currently diverse and complex literature on putative
sleep substances more structured and comprehensible.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1139/cjpp-76-3-284
发表时间:
1998-03-01
期刊:
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
影响因子:
2.1
作者:
[Leslie, FM, Chen, YL, Winzer-Serhan, UH]
通讯作者:
Winzer-Serhan, UH
Uncertainty and stimulant self-administration
-
批准号:8509211
-
项目类别:
-
资助金额:$19.75万
-
财政年份:2013
-
负责人:Paul R Vezina
-
依托单位:
Uncertainty and stimulant self-administration
-
批准号:8696842
-
项目类别:
-
资助金额:$23.7万
-
财政年份:2013
-
负责人:Paul R Vezina
-
依托单位:
Nicotine Exposure: Molecular to Behavioral Consequences
-
批准号:7848837
-
项目类别:
-
资助金额:$4.27万
-
财政年份:2007
-
负责人:Paul R Vezina
-
依托单位:
Nicotine Exposure: Molecular to Behavioral Consequences
-
批准号:7618706
-
项目类别:
-
资助金额:$89.79万
-
财政年份:2007
-
负责人:Paul R Vezina
-
依托单位:
BEHAVIORAL AND DOPAMINERGIC SENSITIZATION TO NICOTINE
-
批准号:7287658
-
项目类别:
-
资助金额:$26.29万
-
财政年份:2007
-
负责人:Paul R Vezina
-
依托单位:
ADMINISTRATIVE CORE
-
批准号:7287653
-
项目类别:
-
资助金额:$6.81万
-
财政年份:2007
-
负责人:Paul R Vezina
-
依托单位:
Nicotine Exposure: Molecular to Behavioral Consequences
-
批准号:8063113
-
项目类别:
-
资助金额:$88.76万
-
财政年份:2007
-
负责人:Paul R Vezina
-
依托单位:
Nicotine Exposure: Molecular to Behavioral Consequences
-
批准号:7812223
-
项目类别:
-
资助金额:$90.77万
-
财政年份:2007
-
负责人:Paul R Vezina
-
依托单位:
Nicotine Exposure: Molecular to Behavioral Consequences
-
批准号:7251767
-
项目类别:
-
资助金额:$87.84万
-
财政年份:2007
-
负责人:Paul R Vezina
-
依托单位:
DOPAMINE NEUROTRANSMISSION AND AMPHETAMINE SENSITIZATION
-
批准号:2013388
-
项目类别:
-
资助金额:$19.36万
-
财政年份:1997
-
负责人:Paul R Vezina
-
依托单位:
DOPAMINE NEUROTRANSMISSION AND AMPHETAMINE SENSITIZATION
-
批准号:2749117
-
项目类别:
-
资助金额:$18.36万
-
财政年份:1997
-
负责人:Paul R Vezina
-
依托单位:
DOPAMINE NEUROTRANSMISSION AND AMPHETAMINE SENSITIZATION
-
批准号:6174789
-
项目类别:
-
资助金额:$17.95万
-
财政年份:1997
-
负责人:Paul R Vezina
-
依托单位:
DOPAMINE NEUROTRANSMISSION AND AMPHETAMINE SENSITIZATION
-
批准号:2897975
-
项目类别:
-
资助金额:$18.66万
-
财政年份:1997
-
负责人:Paul R Vezina
-
依托单位:
Sensitization and Stimulant Self-Administration
-
批准号:8503949
-
项目类别:
-
资助金额:$37.44万
-
财政年份:1995
-
负责人:Paul R Vezina
-
依托单位:
GLUTAMATE AND THE SELF ADMINISTRATION OF AMPHETAMINES
-
批准号:6634211
-
项目类别:
-
资助金额:$20.05万
-
财政年份:1995
-
负责人:Paul R Vezina
-
依托单位:
DOPAMINERGIC SENSITIZATION AND DRUG SELF-ADMINISTRATION
-
批准号:2122587
-
项目类别:
-
资助金额:$15.45万
-
财政年份:1995
-
负责人:Paul R Vezina
-
依托单位:
Sensitization and Stimulant Self-Administration
-
批准号:7071162
-
项目类别:
-
资助金额:$28.71万
-
财政年份:1995
-
负责人:Paul R Vezina
-
依托单位:
Sensitization and Stimulant Self-Administration
-
批准号:6989201
-
项目类别:
-
资助金额:$29.22万
-
财政年份:1995
-
负责人:Paul R Vezina
-
依托单位:
GLUTAMATE AND THE SELF ADMINISTRATION OF AMPHETAMINES
-
批准号:2761709
-
项目类别:
-
资助金额:$18.16万
-
财政年份:1995
-
负责人:Paul R Vezina
-
依托单位:
DOPAMINERGIC SENSITIZATION AND DRUG SELF ADMINISTRATION
-
批准号:2707527
-
项目类别:
-
资助金额:$2.1万
-
财政年份:1995
-
负责人:Paul R Vezina
-
依托单位:
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