Effect of lipid mediators and dietary fats in bone remodelling

脂质介质和膳食脂肪在骨重塑中的作用

• 批准号: nhmrc : 250411
• 负责人: Prof Howard Morris
• 金额: $ 25.36万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-lipid-mediators-bone-remodelling/99110
• 关键词: Effect; lipid; mediators; dietary; fats

Osteoporosis in a major public health problem which directly affects about 10% of the population, which is currently around 2 million Australians. With aging of the population, it is projected that this proportion will increase to more than 13% over the next 20 years. When it is considered that the direct hospital and residential care costs attributable to osteoporotic fractures currently approaches $2 billion per annum, low-cost interventions for increasing bone strength which are easily applied to the elderly population have enormous potential for health benefits in Australia. Thus study will examine the effects of dietary omega-3 fats, of the kind found in fish and fish oil, on the biology of bone metabolism and on bone strength. The results will provide information which may be used in developing simple drug or dietary strategies for large-scale use for increasing bone mass and strength in the elderly population. A strength of the study arises from the combination of research expertise in (a) dietary fats, and (b) molecular biology of bone cells, and (c) animal models of bone metabolism which are amenable to dietary interventions. This combination is unique, but builds on well established systems which hitherto have existed in separate research paradigms. The Chief Investigator has considerable experience in development of diets enriched in omega-3 fats which are practical and suitable for daily use on a long-term basis. This adds considerably to the potential significance of the outcomes because, if favourable effects of omega-3 fats are observed and are characterised with regard to mechanisms, the results can be rapidly translated into large-scale clinical use.

骨质疏松症是一个重大公共卫生问题，直接影响约 10% 的人口，目前约有 200 万澳大利亚人。随着人口老龄化，预计未来20年这一比例将增至13%以上。目前，骨质疏松性骨折导致的直接医院和住院护理费用每年接近 20 亿澳元，易于应用于老年人群的低成本增强骨强度干预措施在澳大利亚具有巨大的健康益处潜力。因此，研究将探讨鱼和鱼油中的膳食 omega-3 脂肪对骨代谢生物学和骨强度的影响。结果将提供可用于开发简单药物或饮食策略的信息，以大规模用于增加老年人口的骨量和强度。该研究的优势在于结合了以下方面的研究专业知识：（a）膳食脂肪，（b）骨细胞的分子生物学，以及（c）适合饮食干预的骨代谢动物模型。这种组合是独特的，但建立在迄今为止存在于不同研究范式中的完善系统之上。首席研究员在开发富含 omega-3 脂肪的饮食方面拥有丰富的经验，这些饮食实用且适合长期日常使用。这大大增加了结果的潜在意义，因为如果观察到 omega-3 脂肪的有利作用并对其机制进行表征，结果可以迅速转化为大规模临床应用。