Inhibition of Bone Resorption Increases Skeletal Mechanical Strength by Thickening Trabecular Structures

该项目将确定一些治疗骨质疏松症的方法降低骨折风险的基础。目前至少有四类此类化合物目前用于治疗骨质疏松症。其中一些已经被发现具有非常明显的有益效果，可以将骨折风险减半。这项研究将确定这些化合物中的每一种是否都有能力将骨骼的机械强度提高到相同的水平，以及每一种化合物是否对骨骼结构具有相同的影响。此外，还将确定通过使骨骼承受机械应力来刺激骨形成对每种疗法的疗效的影响。相反，将研究对骨形成施加限制的老化的影响。

This project will identify the basis by which a number of therapies for osteoporosis decrease the risk of bone fractures. Currently at least four classes of these compounds in current use for the treatment of osteoporosis. Some of them have been found to have a very marked beneficial effect by halving the risk of fracture. This study will determine if each of these classes of compounds have the ability to increase the mechanical strength of bone to the same level and if each of these compounds has the same effects on bone structure. Further the effects of stimulating bone formation by subjecting the skeletal to mechanical stress, on the efficacy of each of the therapies will be established. Conversely the effect of aging, which imposes a limitation on bone formation, will be studied.