Discovering the role of pH in regulating mitochondrial biogenesis, so as to improve the design of preventative programs aimed at healthy ageing

发现pH在调节线粒体生物合成中的作用，从而改进健康衰老预防方案的设计

• 批准号: DP140104165
• 负责人: Prof David Bishop
• 金额: $ 25.17万
• 依托单位: Victoria University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-06-05 至 2018-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140104165
• 关键词: Discovering; role; pH; regulating; mitochondrial

Mitochondria are essential for life, and maintaining mitochondrial function plays an important role in preventing the progression of many age-related diseases. It has previously been shown that minimising the decrease in muscle pH that occurs during physical activity promotes greater improvements in mitochondrial function. The next step is to discover the effects of altering pH on acute and chronic activity-induced changes in signalling proteins and genes that are involved in the regulation of skeletal muscle mitochondrial biogenesis. These experiments will significantly advance the knowledge base concerning factors regulating mitochondrial biogenesis, and will contribute to optimising the design of preventative programs aimed at healthy aging.

线粒体是生命所必需的，维持线粒体的功能在防止许多与年龄相关的疾病的进展中起着重要作用。此前已有研究表明，尽量减少体力活动过程中肌肉pH值的下降，有助于更大程度地改善线粒体功能。下一步是发现改变pH对急性和慢性活动引起的信号蛋白和参与骨骼肌线粒体生物发生调控的基因的变化的影响。这些实验将显著推进有关线粒体生物发生调控因素的知识基础，并将有助于优化旨在健康老龄化的预防计划的设计。