Delineating the Externalizing Construct & Its Facets

描述外化结构

• 批准号: 6529010
• 负责人: CHRISTOPHER JOHN PATRICK
• 金额: $ 44.65万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529010
• 关键词: abnormal psychology; alcoholism /alcohol abuse; antisocial personality; behavioral /social science research tag; behavioral genetics; clinical research; correctional institutions; criminal behavior; drug addiction; evoked potentials; human subject; impulsive behavior; interview; locus of control; model design /development; personality; psychological models; psychological tests; psychometrics; questionnaires; social behavior disorders; suicide; twin /multiplet; violence

DESCRIPTION (provided by applicant): Five years of funding are sought to pursue translational research on the externalizing spectrum of personality and psychopathology. The externalizing spectrum is conceived of as a coherent set of personality traits and psychopathological syndromes characterized by a lack of impulse control. At the highest level within this spectrum stands a variable that links specific externalizing disorders and traits, the externalizing dimension. Recent research demonstrates both the existence and high heritability of this dimension via significant observed (phenotypic) and etiological (genetic) connections between an unconstrained, impulse-driven personality style and psychopathological syndromes involving antisocial behavior and substance dependence. This application seeks to build on these preliminary data by pursuing three specific aims. First, quantitative models of behaviors in the externalizing spectrum will be built by developing a hierarchical model of the externalizing spectrum that links the broad externalizing dimension to its manifestations as specific traits and syndromes. Second, models of externalizing behavior will be linked to models of neurocognitive processing, with a particular focus on event related potentials, to characterize the biobehavioral bases of externalizing behavior. Third, high levels of externalizing will be studied in criminal offender samples to characterize the implications of the externalizing spectrum model for understanding behaviors with high social costs, such as reactive violence and impulsive suicide attempts. This research is designed to realize the aims of the RFA to which it is a response by integrating ideas from diverse scientific areas (ranging from statistical modeling to cognitive neuroscience), in linking basic methodological advances in these areas to a broad range of costly, impulsive behaviors in both clinical and non-clinical samples.

描述（由申请人提供）：五年的资金寻求追求 人格外化谱的转化研究， 精神病理学外化光谱被认为是一个连贯的集合 人格特征和精神病理综合征的特点是缺乏 冲动控制。在这个光谱的最高层， 联系特定的外化障碍和特征，外化 维度最近的研究表明， 通过显著观察（表型）和 病因（遗传）之间的联系不受约束，冲动驱动， 人格类型和精神病理综合征 行为和物质依赖。本申请旨在建立在这些 初步数据，追求三个具体目标。第一，量化模型 行为的外化频谱将建立通过开发一个 外部化频谱的分层模型， 外化的维度，其表现为具体的特点和综合征。 第二，外化行为的模型将与 神经认知处理，特别关注事件相关电位， 来描述外化行为的生物行为基础。三是高 将在刑事犯罪者样本中研究外化水平， 描述外化频谱模型的含义， 理解具有高社会成本的行为，如反应性暴力， 冲动的自杀企图本研究旨在实现 RFA是通过整合来自不同科学领域的想法而做出的回应， 领域（从统计建模到认知神经科学）， 这些领域的基本方法进步， 临床和非临床样本中的冲动行为。