Delineating the Externalizing Construct & Its Facets

描述（由申请人提供）：寻求五年的资助 人格外化谱的转化研究 精神病理学。外化谱被认为是一个相干的集合 人格特质和精神病理综合征的特征是缺乏 的冲动控制。在这个范围内的最高层有一个变量 将特定的外化障碍和特征联系起来 维度。最近的研究表明存在并且高 通过显着观察（表型）和 不受约束的、冲动驱动的之间的病因学（遗传）联系 人格风格和涉及反社会的精神病理综合征 行为和物质依赖。该应用程序旨在建立在这些基础上 通过追求三个具体目标获得初步数据。一、定量模型 外化谱中的行为将通过开发 连接广泛的外部化谱的层次模型 将其表现形式外化为特定特征和综合症。 其次，外化行为模型将与 神经认知处理，特别关注事件相关电位， 表征外化行为的生物行为基础。三、高 将在刑事犯罪者样本中研究外化水平，以 描述外化谱模型的含义 了解具有高社会成本的行为，例如反应性暴力和 冲动自杀企图。本研究旨在实现以下目标 RFA 是对 RFA 的回应，融合了不同科学的观点 领域（从统计建模到认知神经科学），将 这些领域的基本方法论进步涉及广泛的、成本高昂的、 临床和非临床样本中的冲动行为。

DESCRIPTION (provided by applicant): Five years of funding are sought to pursue translational research on the externalizing spectrum of personality and psychopathology. The externalizing spectrum is conceived of as a coherent set of personality traits and psychopathological syndromes characterized by a lack of impulse control. At the highest level within this spectrum stands a variable that links specific externalizing disorders and traits, the externalizing dimension. Recent research demonstrates both the existence and high heritability of this dimension via significant observed (phenotypic) and etiological (genetic) connections between an unconstrained, impulse-driven personality style and psychopathological syndromes involving antisocial behavior and substance dependence. This application seeks to build on these preliminary data by pursuing three specific aims. First, quantitative models of behaviors in the externalizing spectrum will be built by developing a hierarchical model of the externalizing spectrum that links the broad externalizing dimension to its manifestations as specific traits and syndromes. Second, models of externalizing behavior will be linked to models of neurocognitive processing, with a particular focus on event related potentials, to characterize the biobehavioral bases of externalizing behavior. Third, high levels of externalizing will be studied in criminal offender samples to characterize the implications of the externalizing spectrum model for understanding behaviors with high social costs, such as reactive violence and impulsive suicide attempts. This research is designed to realize the aims of the RFA to which it is a response by integrating ideas from diverse scientific areas (ranging from statistical modeling to cognitive neuroscience), in linking basic methodological advances in these areas to a broad range of costly, impulsive behaviors in both clinical and non-clinical samples.