Delineating the Externalizing Construct & Its Facets

描述(由申请者提供)：寻求五年资助 人格外化谱系与人格外化关系的翻译研究 精神变态学。外化光谱被认为是一个相干集合 人格特征和精神病理症状的特征是缺乏 控制冲动的能力。在这个光谱的最高水平上有一个变量 它将特定的外化障碍和特征联系在一起，外化 尺寸。最近的研究证明了这种现象的存在和高度的 这一维度的遗传力通过显著观察(表型)和 在不受约束的、冲动驱动的 人格风格与反社会精神病态综合征 行为和物质依赖。此应用程序寻求建立在这些基础上 通过追求三个具体目标获得初步数据。第一，数量模型 外化光谱中的行为将通过开发一个 链接广泛的外部化频谱的分层模型 将其外化维度表现为特定的特征和症状。 第二，外部化行为的模型将与 神经认知处理，特别关注事件相关电位， 以表征外化行为的生物行为学基础。第三，高 外化程度将在罪犯样本中进行研究，以 描述外部化频谱模型的含义 理解具有高社会成本的行为，如反应性暴力和 冲动的自杀企图。这项研究旨在实现以下目标 RFA是对它的回应，它整合了来自不同科学领域的想法 领域(从统计建模到认知神经科学)，链接 这些领域的基本方法学进步到广泛的、昂贵的、 临床和非临床样本中的冲动行为。

DESCRIPTION (provided by applicant): Five years of funding are sought to pursue translational research on the externalizing spectrum of personality and psychopathology. The externalizing spectrum is conceived of as a coherent set of personality traits and psychopathological syndromes characterized by a lack of impulse control. At the highest level within this spectrum stands a variable that links specific externalizing disorders and traits, the externalizing dimension. Recent research demonstrates both the existence and high heritability of this dimension via significant observed (phenotypic) and etiological (genetic) connections between an unconstrained, impulse-driven personality style and psychopathological syndromes involving antisocial behavior and substance dependence. This application seeks to build on these preliminary data by pursuing three specific aims. First, quantitative models of behaviors in the externalizing spectrum will be built by developing a hierarchical model of the externalizing spectrum that links the broad externalizing dimension to its manifestations as specific traits and syndromes. Second, models of externalizing behavior will be linked to models of neurocognitive processing, with a particular focus on event related potentials, to characterize the biobehavioral bases of externalizing behavior. Third, high levels of externalizing will be studied in criminal offender samples to characterize the implications of the externalizing spectrum model for understanding behaviors with high social costs, such as reactive violence and impulsive suicide attempts. This research is designed to realize the aims of the RFA to which it is a response by integrating ideas from diverse scientific areas (ranging from statistical modeling to cognitive neuroscience), in linking basic methodological advances in these areas to a broad range of costly, impulsive behaviors in both clinical and non-clinical samples.