GENETICS OF ATHEROSCLEROSIS IN MEXICAN AMERICANS

墨西哥裔美国人动脉粥样硬化的遗传学

• 批准号: 6450078
• 负责人: MICHAEL P STERN
• 金额: $ 23.48万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6450078
• 关键词: Mexican Americans; atherosclerosis; cardiovascular disorder epidemiology; clinical research; family genetics; genetic mapping; genetic polymorphism; genetic susceptibility; human subject; noninsulin dependent diabetes mellitus; obesity

This study is part of the San Antonio Family Heart Study, the first comprehensive genetic epidemiological study of atherosclerosis and its correlates in Mexican Americans. Its goal is to detect and map new polymorphic genes that influence variation in susceptibility to cardiovascular disease in Mexican Americans. Because non insulin dependent diabetes mellitus and obesity are risk factors for cardiovascular disease and are common in this population, the pleiotropic effects of diabetes and obesity-related genes on quantitative correlates of cardiovascular disease will also be studied. More than 40 extended families will be studied and a complete risk factor profile will be developed.

这项研究是圣安东尼奥家庭心脏研究的一部分，这是墨西哥裔美国人中第一项全面的动脉粥样硬化及其相关基因流行病学研究。它的目标是检测和定位影响墨西哥裔美国人心血管疾病易感性变异的新的多态基因。由于非胰岛素依赖型糖尿病和肥胖是心血管疾病的危险因素，并且在该人群中很常见，因此我们还将研究糖尿病和肥胖相关基因对心血管疾病数量相关的多重效应。将对40多个大家庭进行研究，并将制定完整的风险因素概况。