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NIDDM PRIMARY PREVENTION TRIAL

NIDDM PRIMARY PREVENTION TRIAL
NIDDM 一级预防试验
批准号：
6450086
负责人：
STEVEN M. HAFFNER
金额：
$23.48万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-12-01 至 2001-11-30
来源：
https://reporter.nih.gov/project-details/6450086
关键词：
blood lipid blood lipoprotein blood pressure clinical research clinical trials diet therapy disease /disorder prevention /control exercise glucose tolerance human subject metabolism disorder chemotherapy noninsulin dependent diabetes mellitus

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中文摘要
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英文摘要
This multi-center study will attempt to prevent the development of NIDDM in 200 subjects with impaired glucose tolerance. This is a four-arm trial: usual care lifestyle plus placebo for pharmacological therapy; intensive lifestyle (special diet and exercise) plus placebo for pharmacological therapy; usual care lifestyle and Metformin; usual care lifestyle and Troglitazone The primary endpoint will be the development of NIDDM. Secondary endpoints include changes in lipids, lipoproteins, ankle/arm blood pressure ratio, urinary albumin and carotid wall thickness.
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