INSULIN, INSULIN RESISTANCE, HYPERGLYCEMIA & CARDIOVASCULAR DISEASE

非胰岛素依赖型糖尿病（NIDDM）与风险增加有关 用于冠状动脉、外周血管和脑血管疾病。 它 已经假设心血管疾病（CVD）不是一种 NIDDM的后果，但这两种情况有共同之处 前因 风险因素如肥胖、高空腹血糖和 低水平的总和低密度脂蛋白胆固醇浓度 高密度脂蛋白胆固醇，高血压， 血糖正常的受试者随后发生血糖受损 宽容 这项研究旨在确定胰岛素抵抗是否是 与独立于肥胖的CVD患病率增加相关， 胰岛素抵抗和胰岛素血症，以确定胰岛素抵抗对 CVD危险因素，以确定是否有种族差异， 胰岛素抵抗与心血管疾病患病率之间的关系， 建立一个前瞻性研究的基础，以确定胰岛素抵抗是否 预测心血管疾病的发展及其危险因素。

Non-insulin dependent diabetes (NIDDM) is associated with increased risk for coronary artery, peripheral vascular, and cerebrovascular diseases. It has been hypothesized that cardiovascular disease (CVD) is not a consequence of NIDDM but that both conditions share common antecedents. Risk factors such as obesity, high fasting plasma glucose and total and low-density lipoprotein cholesterol concentrations with low levels of high-density lipoprotein cholesterol, high blood pressure -- all cluster in normoglycemic subjects who subsequently develop impaired glucose tolerance. This study proposes to determine if insulin resistance is associated with increased prevalence of CVD independent of obesity, glycemia, and insulinemia, to determine the impact of insulin resistance on CVD risk factors, to determine if there are ethnic differences in the relationship between insulin resistance and the prevalence of CVD, and to establish the basis for a prospective study to determine if insulin resistance predicts the development of CVD and its risk factors.