MOLECULAR MICROBIOLOGY TRAINING GRANT

描述（由申请人提供）：德州大学达拉斯西南医学中心要求继续支持研究生和研究生分子微生物学培训计划（MMTP）。这个MMTP的一个特别吸引人的特点是它从传统的基于项目或部门的培训转变为跨学科的培训，保持了微生物学的方向，同时扩大了培训任务的范围，包括分子和细胞生物学的许多其他方面。“23名培训师的背景各异，包括一组有成就记录的知名研究人员和不断扩大的新教员，他们代表着以分子和细胞微生物学为共同主题的跨学科研究项目。”培训教员来自八个不同的医学院院系。总体目标是培养学生和博士后从事微生物发病机制、细胞微生物学、宿主防御机制、疫苗开发和结构生物学的分子基础研究。MMTP每年资助6个博士预科（博士或医学博士/博士）和3个博士后（博士或医学博士）。一般来说，获得博士学位的活动包括(1)通过定制的、灵活的培训轨道完成课程，(2)参加研讨会和期刊俱乐部，(3)在书面资格考试中取得成绩，(4)每年参加MMTP研究论坛，(5)在博士论文答辩中进行密集的研究培训。博士后（博士或医学博士）将有机会巩固基本技能，发展独立的科学思维和研究计划，并学习新的基础科学探究或技术领域。研究员还将参与研究生教学，在期刊俱乐部和研究研讨会上发表演讲，并为推动科学进步的总体“发酵”做出贡献。我们期望学员在完成本课程后能够熟练运用微生物学、生物化学、分子遗传学、基因阵列、生物信息学、结构生物学、细胞生物学和免疫学的现代方法来解决微生物科学中的重要问题，并改进预防和治疗干预策略。MMTP目前只有4年的历史，但已经有证据表明它取得了巨大的成功。为征聘人数不足的少数民族所作的特别努力将继续取得成功。德州大学西南医学中心提供了一个优秀的研究环境，在这个环境中继续进行分子微生物学的进步，当代培训计划。

DESCRIPTION (provided by applicant): U.T. Southwestern Medical Center at Dallas requests continued support for a graduate and post-graduate Molecular Microbiology Training Program (MMTP). A particularly attractive feature of this MMTP is its departure from conventional program- or departmental-based training to an interdisciplinary program that maintains a microbiology orientation while, at the same time, broadens the scope of the training mission to include many other aspects of molecular and cell biology. 'The diverse backgrounds of the 23 trainers, comprised of a core group of established investigators with accomplished records and an expanding new faculty, represent interdisciplinary research programs bound by the common theme of molecular and cellular microbiology. The training faculty emanate from eight different medical school departments. The overall objective is to train students and postdoctoral fellows for research careers in the molecular basis of microbial pathogenesis, cellular microbiology, host defense mechanisms, vaccine development, and structural biology. The MMTP requests funding for 6 pre-doctoral (Ph.D. or M.D./Ph.D.) and 3 post-doctoral positions (Ph.D. or M.D.) each year. In general, activities towards the Ph.D. degree include (1) course work via a customized, flexible training track, (2) attendance and participation in seminars and journal clubs, (3) achievement on written qualifying examinations, (4) annual attendance at a MMTP Research Forum, and (5) intensive research training culminating in the defense of a doctoral dissertation. Post-doctoral fellows (Ph.D. or M.D.) will be provided the opportunity to consolidate basic skills, develop independence in scientific thinking and research planning, and learn new areas of basic scientific inquiry or technology. Fellows also will be involved in teaching graduate students, presenting journal clubs and research seminars, and contributing to the general "ferment" that drives scientific progress. We expect trainees who complete this program to become skilled in applying contemporary approaches in microbiology, biochemistry, molecular genetics, gene arrays, bioinformatics, structural biology, cell biology, and immunology to important problems in the microbiological sciences and to the improvement of preventive and therapeutic intervention strategies. The MMTP currently is only four years old, but there already is evidence of substantial success. Special efforts for the recruitment of under-represented minorities, which already have been successful, will continue. U.T. Southwestern Medical Center offers an outstanding research environment in which to continue this progressive, contemporary training program in molecular microbiology.