Probing the skeletal stem cell niche through functional investigation of Prx1 expressing cells.

通过 Prx1 表达细胞的功能研究来探索骨骼干细胞生态位。

• 批准号: 1819509
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1819509
• 关键词: Probing; skeletal; stem; cell; niche

Using current knowledge, this project aims to address the possibility of a tissue resident Prx1 expressing Skeletal Stem Cell using an integrated developmental biology and stem cell approach. Elucidation of the location and constituents of the skeletal stem cell niche his may open the door for novel pharmaceutical development that can target the stem cells in vivo for tissue formation, allow duplication of the niche ex vivo for stem cell investigation, or generate therapies for dysfunctional niches that occur due to disease or aging.

利用目前的知识，该项目旨在解决组织居民Prx1表达Skills干细胞使用综合发育生物学和干细胞方法的可能性。阐明骨骼干细胞小生境的位置和成分可能为新的药物开发打开大门，该药物开发可以靶向体内干细胞用于组织形成，允许离体复制小生境用于干细胞研究，或产生用于由于疾病或衰老而发生的功能失调小生境的疗法。