Development of B(MIDA)-based directing groups for C-H functionalization

开发基于 B(MIDA) 的 C-H 功能化导向基团

• 批准号: 1829120
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1829120
• 关键词: Development; MIDA; based; directing; groups

The practical advantages of using 'protected' boronic acid derivatives such as B(MIDA) derivatives will be expanded to permit their use as functional directing groups for transition metal catalyzed C-H functionalization ortho of aryl-B(OH)2 derivatives as well as for alkenyl-Csp2 and alkyl-Csp3 functionalizaiton. Givent he wide spread commercialization of these functionalities, we expect that a successful demonstration of these new directing B(MIDA) derivatives will be of importance to chemical industries, including the pharmaceutical, agrochemical, and material industries.

使用“受保护的”硼酸衍生物如B（MIDA）衍生物的实际优点将被扩展以允许它们用作用于芳基-B（OH）2衍生物的邻位的过渡金属催化的C-H官能化以及用于烯基-Csp 2和烷基-Csp 3官能化的官能导向基团。鉴于这些功能性的广泛商业化，我们期望这些新的定向B（MIDA）衍生物的成功示范将对化学工业（包括制药、农用化学品和材料工业）具有重要意义。

项目成果

meta-Selective C-H functionalisation of aryl boronic acids directed by a MIDA-derived boronate ester.

• DOI: 10.1039/d0sc00230e
• 发表时间: 2020-03-03
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Williams AF;White AJP;Spivey AC;Cordier CJ
• 通讯作者: Cordier CJ