Defining shared and distinct genetic/genomic mechanisms that underlie the impact of environmental factors on lung function

定义环境因素对肺功能影响的共同和独特的遗传/基因组机制

• 批准号: 1832356
• 金额: --
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1832356
• 关键词: Defining; shared; distinct; genetic; genomic

Human physiological traits are influenced by a range of genetic, epigenetic and environmental factors. The development of genetic, informatics and biological systems based workflows that allow us to use a combination of large scale human phenotypic, genetic and genomic data will increase our understanding of traits such as lung function.This project will involve analysis of the rich phenotypic and genetic data now available from a new local cohort, the EXCEED (EXtended Cohort for E-health, Environment and DNA) study (6500 individuals), to study environmental and genetic effects on lung function. These available data include primary care electronic medical records with information on attendance, diagnoses, prescriptions and pathology results. These data will be integrated with measurements for more than 25 million genetic variants and used to analyse the relationships between lung function parameters and environmental stresses. A key focus of the project will be the effect of pathogen infection on lung health leading to insight into the mechanisms underlying exacerbations, and potential therapeutic interventions, in respiratory diseases such as Chronic Obstructive Pulmonary Disease (COPD).The student will join a group leading high-profile respiratory genomics research and will have access to excellent training facilities and research opportunities within the Universityand in partnership with GSK. A minimum of 12 weeks will be spent on placement at GSK over the course of the studentship.The studentship will be under the supervision of Professor Martin Tobin (Department of Health Sciences, University of Leicester) and Dr David Michalovich (GSK) and will involve collaboration with colleagues in and outside Leicester, thus ensuring a rich research environment at the interface of statistics, medicine and genetics. Genetic epidemiology is a growing field with excellent postdoctoral employment opportunities.

人类的生理特征受到一系列遗传、表观遗传和环境因素的影响。基于遗传学、信息学和生物学系统的工作流程的发展，使我们能够使用大规模人类表型、遗传学和基因组数据的组合，这将增加我们对肺功能等性状的理解。该项目将涉及分析新的本地队列EXCEED中现有的丰富表型和遗传数据。（扩展队列电子健康，环境和DNA）研究（6500人），研究环境和遗传对肺功能的影响。这些可用数据包括初级保健电子医疗记录，其中包括有关出勤、诊断、处方和病理结果的信息。这些数据将与超过2500万个遗传变异的测量结果相结合，并用于分析肺功能参数与环境压力之间的关系。该项目的一个重点是病原体感染对肺部健康的影响，从而深入了解病情加重的机制和潜在的治疗干预措施，在呼吸系统疾病，如慢性阻塞性肺疾病（COPD）。学生将加入一个小组领导高-简介呼吸基因组学研究，并将有机会获得优秀的培训设施和大学内的研究机会，并与葛兰素史克。该研究生项目将在莱斯特大学健康科学系的Martin Tobin教授和GSK的大卫Michalovich博士的指导下进行，并将与莱斯特内外的同事合作，从而确保在统计学，医学和遗传学的界面上提供丰富的研究环境。遗传流行病学是一个不断发展的领域，有很好的博士后就业机会。

项目成果

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.

• DOI: 10.1038/s41467-023-42284-5
• 发表时间: 2023-10-23
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Williams, Alexander T.;Chen, Jing;Coley, Kayesha;Batini, Chiara;Izquierdo, Abril;Packer, Richard;Abner, Erik;Kanoni, Stavroula;Shepherd, David J.;Free, Robert C.;Hollox, Edward J.;Brunskill, Nigel J.;Ntalla, Ioanna;Reeve, Nicola;Brightling, Christopher E.;Venn, Laura;Adams, Emma;Bee, Catherine;Wallace, Susan E.;Pareek, Manish;Hansell, Anna L.;Esko, Tonu;Stow, Daniel;Jacobs, Benjamin M.;van Heel, David A.;Rao, Balasubramanya S.;Hennah, William;Rao, Balasubramanya S.;Dudbridge, Frank;Wain, Louise V.;Shrine, Nick;Tobin, Martin D.;John, Catherine
• 通讯作者: John, Catherine

Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers.

• DOI: 10.1186/s12916-023-03109-w
• 发表时间: 2023-11-30
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Ekezie, Winifred;Martin, Christopher A.;Baggaley, Rebecca F.;Teece, Lucy;Nazareth, Joshua;Pan, Daniel;Sze, Shirley;Bryant, Luke;Woolf, Katherine;Gray, Laura J.;Khunti, Kamlesh;Pareek, Manish
• 通讯作者: Pareek, Manish

Genome-wide association study of preserved ratio impaired spirometry (PRISm).

• DOI: 10.1183/13993003.00337-2023
• 发表时间: 2024-01
• 期刊: EUROPEAN RESPIRATORY JOURNAL
• 影响因子: 24.3
• 作者: Higbee, Daniel H.;Lirio, Alvin;Hamilton, Fergus;Granell, Raquel;Wyss, Annah B.;London, Stephanie J.;Bartz, Traci M.;Gharib, Sina A.;Cho, Michael H.;Wan, Emily;Silverman, Edwin;Crapo, James D.;Lominchar, Jesus V. T.;Hansen, Torben;Grarup, Niels;Dantoft, Thomas;Karhus, Line;Linneberg, Allan;O'Connor, George T.;Dupuis, Josee;Xu, Hanfie;De Vries, Maaike M.;Hu, Xiaowei;Rich, Stephen S.;Barr, R. Graham;Manichaikul, Ani;Wijnant, Sara R. A.;Brusselle, Guy G.;Lahousse, Lies;Li, Xuan;Cordero, Ana I. Hernandez;Obeidat, Ma'en;Sin, Don D.;Harris, Sarah E.;Redmond, Paul;Taylor, Adele M.;Cox, Simon R.;Williams, Alexander T.;Shrine, Nick;John, Catherine;Guyatt, Anna L.;Hall, Ian P.;Smith, George Davey;Tobin, Martin D.;Dodd, James W.
• 通讯作者: Dodd, James W.

Association study of human leukocyte antigen (HLA) variants and idiopathic pulmonary fibrosis.

人类白细胞抗原（HLA）变异与特发性肺纤维化的关联研究。

• DOI: 10.1101/2023.07.20.23292940
• 发表时间: 2023
• 期刊: the preprint server for health sciences
• 作者: Guillen-Guio B