Dual Use of ENDS and Combustible Cigarettes: Shared, Distinct, and Cross-Conditioned Processes

ENDS 和可燃卷烟的双重用途：共享、独特和交叉处理流程

• 批准号: 10377397
• 负责人: Alexander William Sokolovsky
• 金额: $ 19.52万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10377397
• 关键词: Acute; Affect; Affective; Age; Applications Grants; Attention; Award; Behavior assessment; Behavioral; Cigarette; Clinical Trials; Cues; Data; Development; Devices; Drug Addiction; Drug Exposure; Drug Modelings; Drug usage; Ecological momentary assessment; Electronic Nicotine Delivery Systems; Environment; Event; Exposure to; Focus Groups; Image; Incentives; Individual; Intervention; Knowledge; Laboratories; Laboratory Finding; Laboratory Study; Longitudinal Studies; Measures; Mentors; Methodology; Methods; Modeling; Moods; Motivation; Negative Reinforcements; Nicotine Dependence; Participant; Patient Self-Report; Pattern; Persons; Pharmaceutical Preparations; Population Assessment of Tobacco and Health; Positive Reinforcements; Predictive Factor; Preparation; Process; Process Assessment; Public Health; Relapse; Research; Research Project Grants; Research Training; Risk; Role; Sampling; Scientific Inquiry; Series; Smoking; Stimulus; Surveys; Time; Tobacco; Tobacco use; Training; Translating; Translation Process; Translations; Visual; Youth; adaptive intervention; attentional bias; base; cigarette smoking; cognitive process; combustible cigarette; combustible tobacco; conditioning; craving; cue reactivity; drug craving; enhancing factor; in vivo; indexing; individual response; innovation; insight; multilevel analysis; negative affect; nicotine exposure; nicotine use; novel; preventive intervention; protective effect; prototype; response; social; substance use; theories; tobacco products; tobacco user; uptake; vaping; young adult

PROJECT SUMMARY This K08 research and training award will enable the PI to attain the substantive and methodological expertise necessary to conduct independent research on nicotine use in young adults and to translate this knowledge to clinical trial development. Dual use of electronic nicotine delivery system (ENDS) and combustible cigarettes is the most prevalent pattern of tobacco use among US young adults (age 18–25). Characterizing shared, distinct, and cross-conditioned processes that maintain dual use is essential for informing interventions against smoking among vulnerable dual users. The incentive sensitization and affect processing models of drug addiction highlight how drug cues and attentional bias for cues are central drivers of drug craving and use and how negative affect strengthens these relationships. I propose to examine the degree to which these three processes (cue-reactivity, attentional bias, and negative affect) underlie tobacco craving and in laboratory and naturalistic settings among a sample of young adult dual users (n = 80). Significant innovations include examining cross-product conditioning of cues in young adult dual users; integrating data across laboratory and naturalistic settings; and identifying shared and distinct processes in ENDS versus combustible cigarettes. I will examine the effects that in-vivo neutral, ENDS, or combustible cigarette cues have on craving for usual-brand cigarettes or preferred ENDS devices in three laboratory sessions. A visual probe task will index attention bias; participants will self-report positive and negative affect. EMA will be used to gather real-time data from the same participants evaluating predictors of tobacco use and craving that correspond to laboratory measures (mood, tobacco cues), as well as salient social and behavioral correlates. Person- and event-level effects of cue reactivity, attentional bias, cross-product conditioning, and the interactive effect of negative affect will be modeled using multilevel modeling. Results will elucidate the contribution of attentional, mood, and cue-related processes to craving and dual use. Findings will inform development of two research projects: a longitudinal study using survey, EMA, and laboratory methods to characterize the intra-individual behavioral processes underlying transitions through smoking patterns (especially progression from ENDS to dual user); and preparation for a clinical trial of a novel just-in-time adaptive intervention (JITAI) targeting dual users who are either high or low in markers of vulnerability (e.g., cross-product reactivity). A final series of focus groups will assess the receptivity and acceptability of prototype study-informed JITAI components. Highly skilled mentors, including Kristina Jackson, Suzanne Colby, Andrea King, Tyler Wray, and Rachel Cassidy and collaborator Christopher Kahler will provide guidance on training aims: (1) behavioral laboratory assessment methods; (2) analysis and integration of laboratory and naturalistic data; and (3) translation of laboratory findings to JITAI. Overall, the research and training outlined in this application informs key gaps in models of tobacco dual use, and will prepare the PI to conduct independent research furthering scientific inquiry in this field.

项目摘要 这个K 08研究和培训奖将使PI获得实质性和方法学专业知识， 有必要对年轻人的尼古丁使用进行独立研究，并将这些知识转化为 临床试验开发。电子尼古丁输送系统（ENDS）和可燃香烟的双重使用 美国年轻人（18-25岁）中最普遍的烟草使用模式。以共享为特征， 保持双重用途的独特和交叉条件的过程对于为预防和控制艾滋病毒/艾滋病的干预提供信息至关重要。 吸烟的弱势群体。药物的激励敏感化和情感加工模型 成瘾强调了药物线索和对线索的注意力偏差是药物渴望和使用的主要驱动力， 负面影响如何强化这些关系。我想研究一下这三个问题 过程（线索反应，注意力偏差和负面影响）是烟草渴望的基础，在实验室和 年轻成人双重使用者样本中的自然环境（n = 80）。重大创新包括 检查年轻成年双重用户的线索的交叉产品条件反射;整合实验室和 自然环境;以及识别ENDS与可燃香烟的共同和独特过程。我会 检查体内中性、ENDS或可燃香烟线索对渴望普通品牌的影响 香烟或首选的ENDS设备在三个实验室会议。视觉探测任务将指示注意偏向; 参与者将自我报告积极和消极的影响。EMA将用于收集来自 相同的参与者评估与实验室测量相对应的烟草使用和渴望的预测因素 (mood烟草线索），以及显著的社会和行为相关性。个人和事件层面的影响 线索反应性、注意偏差、交叉产品条件反射和负面情绪的交互作用将被 使用多层次建模进行建模。结果将阐明注意力，情绪和线索相关的贡献 渴望和双重用途的过程。调查结果将告知两个研究项目的发展：一个纵向 使用调查、EMA和实验室方法来描述个体内部行为过程的研究 通过吸烟模式的潜在转变（特别是从ENDS到双重使用者的进展）;以及 为一项针对双重使用者的新型即时适应性干预（JITAI）的临床试验做准备， 脆弱性标记的高或低（例如，交叉产物反应性）。最后一系列焦点小组将 评估原型研究知情JITAI组件的接受性和可接受性。高技能的导师， 包括克里斯蒂娜杰克逊，苏珊娜科尔比，安德烈国王，泰勒雷，和雷切尔卡西迪和合作者 Christopher Kahler将提供培训目标的指导：（1）行为实验室评估方法;（2） 分析和整合实验室和自然数据;（3）将实验室结果翻译成JITAI。 总体而言，本申请中概述的研究和培训为烟草双重用途模式中的主要差距提供了信息， 并将准备PI进行独立的研究，促进这一领域的科学探究。