HIV Pathogenesis, prevention and treatment in the Andes

描述（由申请人提供）：这影响健康和教育/学校 公共卫生和秘鲁卡耶塔诺大学埃雷迪亚R 03申请 申请资金以计划和准备CIPRA多项目申请 秘鲁和安第斯区域的P01申请。本次CIPRA的主题将 在安第斯地区预防、发病和治疗艾滋病毒/艾滋病。 秘鲁反种族主义和种族歧视委员会的总体目标是： 与艾滋病毒有关的研究的体制和调查能力 通过行政、实验室、 社区事务/行为研究，生物统计学/数据管理和 发展/培训核心;以及2）支持特定的研究项目， 对秘鲁和拉丁美洲安第斯地区特别重要。的 CIPRA包括5个核心：A）管理。B）实验室。C）生物统计学。D）、 社区教育和发展;以及E）发展和培训。的 CIPRA核心将提供培训、研究和行政支持， 为在秘鲁进行的艾滋病毒研究提供技术专门知识，并将直接 支持多达六个重大研究项目和小型发展研究 秘鲁CIPRA P01应用程序中的项目。所有核心都有监督核心 委员会，并有核心协调员的监督职位。具体 在P0 I申请中提出的主要研究项目建立在以前的基础上， 过去几年在秘鲁进行的NIH资助的研究项目， a）研究性病和艾滋病毒之间的生物学和流行病学相互作用 为了开发和进行生物医学干预试验， STD和HIV传播; B）为了测试免疫学和临床结果， 依从性和抗逆转录病毒耐药性的简单抗逆转录病毒方案 艾滋病毒感染者; c）评估行为干预的有效性 对男男性行为者进行干预，以减少危险行为和性病/艾滋病发病率; d） 确定一般人口与核心人口之间的性别混合模式 在秘鲁，特别是女性性工作者和双性恋男子群体;并评估 一项社区随机性病/艾滋病预防试验; e）评估 流行病学、预防传播和治疗耐多药 （f）查明安第斯区域艾滋病毒感染者的结核病发病率; 快速诊断战略和有效干预措施，以减少围产期 逆转录病毒的传播，特别是艾滋病毒。目前尚不清楚 艾滋病毒感染的治疗经验，或提供了什么 为秘鲁医生提供培训， 抗逆转录病毒疗法

DESCRIPTION (provided by applicant): This Impacta Salud y Educacion/School of Public Health and Universidad Peruana Cayetano Heredia R03 application requests funding to plan and prepare an application for a CIPRA multi-project P01 application for Peru and the Andean region. The theme of this CIPRA will be prevention, pathogenesis and treatment of HIV/AIDS in the Andean region. The overall aims of the Peru CIPRA are: l) to further develop regional, institutional and investigative capacity for research related to HIV prevention, vaccine and treatment through administrative, laboratory, community affairs/behavioral research, biostatistics/data management and developmental/training cores; and 2) to support specific research projects of particular importance to Peru and the Andean region of Latin America. The CIPRA includes 5 cores: A) Administration. B) Laboratory. C) Biostatistics. D) Community Education and development; and E) Developmental and training. The CIPRA cores will provide training, research and administrative support, and technical expertise for HIV research conducted in Peru, and will directly support up to six major research projects and small developmental research projects in the Peru CIPRA P01 application. All cores have oversight Core Committees, and have core coordinator positions for supervision. The specific major research projects to be proposed in the P0I application build on prior NIH-funded research projects conducted in Peru over the past several years and are: a) To study biologic and epidemiologic interactions between STDs and HIV in order to develop and conduct trials of biomedical interventions to reduce STD and HIV transmission; b) To test immunologic and clinical outcomes, adherence, and antiretroviral resistance with a simple antiretroviral regimen in persons with HIV infection; c )To assess the efficacy of a behavioral intervention among MSM in reducing risk behaviors and STD/HIV incidence; d)To determine patterns of sexual mixing between the general population and core groups in Peru, particularly female sex workers and bisexual men; and evaluate a community-randomized STD/HIV prevention trial; e) To assess the epidemiology, prevention of transmission and treatment of multi-drug resistant tuberculosis in HIV-infected persons in the Andean Region; and, f)To identify rapid diagnostic strategies and effective interventions to reduce perinatal transmission of retroviruses, particularly HIV. It is not clear what experience is present in the treatment of HIV infection, or what provision is made to provide training for Peruvian physicians in the administration of antiretroviral therapies.