Effectiveness of ghrelin receptor agonists to limit the extent of tissue damage caused by traumatic injury to the central nervous system

胃饥饿素是一种自然产生的化合物，在不利条件下可以激活身体周围细胞上的特定受体，以提高它们的存活率。这些受体也存在于脊髓中，但胃饥饿素不会进入脊髓。我们将研究一组新的化合物，它们可以进入脊髓并激活这些受体，看看这是否能减少脊髓损伤后发生的损伤量。更少的组织损伤意味着更少的永久性残疾。

Ghrelin is a naturally occurring compound that under adverse conditions can activate specific receptors on cells around the body to enhance their survival. These receptors are also present in the spinal cord, but ghrelin doesn't enter the spinal cord. We will investigate a new group of compounds that can enter the spinal cord and activate these receptors to see if this can reduce the amount of damage that occurs after a spinal cord injury. Less tissue damage would mean less permanent disability.