Chemical Characterisation of New Psychoactive Substances and Evaluating their implications on Human Health and Wellbeing

对秘密药物化合物的化学特性鉴定主要用于两种情况，一种是在法医学上进行个案比较，另一种是作为更广泛的国家和国际警察和执法情报举措的一部分。目前的许多研究侧重于分析安非他明、甲基安非他明和摇头丸等合成化合物中的有机杂质，或通过分析和解释海洛因和可卡因非法混合物中占主导地位的半合成化合物和天然生物碱混合物的杂质概况。尚未就新的精神活性物质开展此类工作。其次，尚未对不同制剂（粉剂、片剂等）进行靶向免疫毒性研究。苯丙胺类兴奋剂或苯丙胺类兴奋剂制剂。轶事证据表明，由于配方改变而产生的多态性可能会产生特定的和潜在的严重健康影响，包括增加发病风险。目前对这些类型的物质的短期或长期健康影响的了解很少。该项目有两个目标。我们将寻求合成和创建一个地面实况数据库的化学特征的苯并咪唑和苯丙胺类兴奋剂化合物。这将有助于国家和国际执法机构查明这些材料，为情报主导的毒品破坏战略提供框架。第二，该项目将产生进行适当的神经毒性研究所需的苯丙胺类兴奋剂和苯丙胺类兴奋剂标准，为了解与摄入这些物质有关的短期、中期和长期健康影响奠定基础。据估计，英国每周有60万人使用这种材料，这将是第一次全面评估滥用这种材料的医疗影响的研究。

Chemical characterisation of clandestine drug compounds is used primarily in two circumstances, in forensic case to case comparisons and as part of wider national and international police and law enforcement intelligence initiatives. Much research currently focuses on the analysis of organic impurities in synthetically produced compounds such as amphetamine, methylamphetamine and ecstasy or through the analysis and interpretation of impurity profiles of a mixture of semi synthetic compounds and naturally occurring alkaloids which predominate in illicit mixtures of heroin and cocaine. No such work has been carried out on New Psychoactive Substances (NPS). Secondly, no targeted immunotoxicity research has been undertaken on different formulations (powders, tablets etc.) of amphetamine type stimulants (ATS) or NPS formulations. Anecdotal evidence suggests that polymorphisms which may be produced as a result of alteration in formulation may create specific and potentially severe health effects including increase risk of morbidity. There is currently little if any understanding of the short or long term health effects of these types of substances. The objectives of this project are twofold. We will seek to synthesise and create a ground truth data base of chemically characterised NPS and ATS compounds. This will aid National and International law enforcement agencies in the identification of these materials providing a framework for intelligence led drug disruption strategies. Secondly, this project will generate the NPS and ATS standards required to undertake the appropriate neurotoxicity studies creating the foundation for understanding the short, medium and long term health implications relating to the ingestion of these substances. With an estimated 600,000 users of NPS in the UK per week this will be the first comprehensive study assessing the medical implications of the abuse of such materials.