Advanced characterisation of drug-carrier interactions to accelerate prediction of new nanomedicines

药物-载体相互作用的高级表征，以加速新纳米药物的预测

• 批准号: 2742228
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2742228
• 关键词: Advanced; characterisation; drug; carrier; interactions

Low solubility active pharmaceutical ingredients (APIs) can have life-changing medicinal effects on patients but can cause significant challenges in the drug development process. The use of amphiphilic excipients is often considered to increase the amount of dissolved API in the solution, thereby enabling administration of the drug, and so micellar systems have gained significant interest due to their nanosize, versatility and scalability. As a result of their complex nature, fundamentally understanding the changes in the properties of a given micellar solution during supersaturation has enormous implications for the development of new medicines, for example by enhancing solubility and enabling better delivery of APIs. Therefore, a fundamental understanding of the interactions between an API and such assemblies, as well as a mechanistic investigation of drug supersaturation needs to be defined. Advanced characterisation techniques will allow a nanoscale and molecular-level understanding of this process.1,2 This understanding will allow rational development of novel micellar systems.The following two main areas are being considered of high importance: - formulation of micellar systems and how they link with solubilising power and physical stability. - extensive characterization of the supersaturation events in micellar formulations using state of the art facilities to pre-empt physical stability issues.The outcomes of the project will inform the development of new, efficacious, and safe medicines for patients. The student will gain skills in cutting-edge formulation design, NMR, scattering, and computational techniques, equipping them for research excellence in industry or academia.

低溶解度活性药物成分（API）可以对患者产生改变生活的药效，但可能会在药物开发过程中带来重大挑战。两亲性赋形剂的使用通常被认为增加了溶液中溶解的API的量，从而能够施用药物，因此胶束系统由于其纳米尺寸、多功能性和可扩展性而获得了显著的兴趣。由于其复杂的性质，从根本上理解给定胶束溶液在过饱和期间的性质变化对新药的开发具有巨大的影响，例如通过提高溶解度和实现API的更好递送。因此，需要定义对API和这样的组件之间的相互作用的基本理解，以及对药物过饱和的机理研究。先进的表征技术将允许对这一过程的纳米级和分子水平的理解。1，2这种理解将允许合理开发新的胶束系统。以下两个主要领域被认为是非常重要的：-胶束系统的配制以及它们如何与增溶能力和物理稳定性联系起来。- 使用最先进的设备对胶束制剂中的过饱和事件进行广泛表征，以预防物理稳定性问题。该项目的成果将为患者开发新的，有效的和安全的药物提供信息。学生将获得尖端配方设计，NMR，散射和计算技术的技能，为他们在工业或学术界的卓越研究提供装备。