Advanced characterisation of drug-carrier interactions to accelerate prediction of new nanomedicines

药物-载体相互作用的高级表征，以加速新纳米药物的预测

• 批准号: 2742228
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2742228
• 关键词: Advanced; characterisation; drug; carrier; interactions

Low solubility active pharmaceutical ingredients (APIs) can have life-changing medicinal effects on patients but can cause significant challenges in the drug development process. The use of amphiphilic excipients is often considered to increase the amount of dissolved API in the solution, thereby enabling administration of the drug, and so micellar systems have gained significant interest due to their nanosize, versatility and scalability. As a result of their complex nature, fundamentally understanding the changes in the properties of a given micellar solution during supersaturation has enormous implications for the development of new medicines, for example by enhancing solubility and enabling better delivery of APIs. Therefore, a fundamental understanding of the interactions between an API and such assemblies, as well as a mechanistic investigation of drug supersaturation needs to be defined. Advanced characterisation techniques will allow a nanoscale and molecular-level understanding of this process.1,2 This understanding will allow rational development of novel micellar systems.The following two main areas are being considered of high importance: - formulation of micellar systems and how they link with solubilising power and physical stability. - extensive characterization of the supersaturation events in micellar formulations using state of the art facilities to pre-empt physical stability issues.The outcomes of the project will inform the development of new, efficacious, and safe medicines for patients. The student will gain skills in cutting-edge formulation design, NMR, scattering, and computational techniques, equipping them for research excellence in industry or academia.

低溶解度活性药物成分（API）可能会对患者产生改变生活的药物影响，但在药物开发过程中可能会引起重大挑战。通常认为使用两亲性赋形剂来增加溶液中溶解的API量，从而使药物给药，因此胶束系统由于其纳米化，多功能性和可扩展性而引起了极大的兴趣。由于其复杂的性质，从根本上了解过度饱和过程中给定胶束溶液的性质的变化对新药物的开发具有巨大的影响，例如，通过增强溶解度并使API更好地递送。因此，需要定义对API与此类组件之间的相互作用的基本理解，以及对药物过饱和的机械研究。先进的表征技术将允许对这一过程的纳米级和分子水平的理解。1,2这种理解将使新型胶束系统合理地发展。以下两个主要领域被认为具有很高的重要性： - 胶束系统的配方以及它们如何与溶解能力和物理稳定性联系在一起。 - 使用最先进的设施来避免身体稳定性问题，对胶束配方中的过饱和事件进行了广泛的表征。该项目的结果将为患者的新，有效和安全的药物的开发提供信息。该学生将获得尖端配方设计，NMR，散射和计算技术的技能，为他们提供工业或学术界卓越的研究。