PERIADOLESCENT MDMA--LONG TERM NEUROBEHAVIORAL EFFECTS

青春期摇头丸——长期神经行为影响

• 批准号: 6378446
• 负责人: KYLE J. FRANTZ
• 金额: $ 4.02万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6378446
• 关键词: 3,4 methylenedioxymethamphetamine; age difference; animal puberty; behavior test; behavioral /social science research tag; cocaine; drug abuse; gender difference; glutamates; injection /infusion; laboratory rat; mature animal; mesencephalon; microdialysis; neural transmission; neuropsychology; neurotoxicology; nucleus accumbens; prosencephalon; psychopharmacology; reinforcer; serotonin; substance abuse related behavior; tegmentum

Despite societal trends for drug abuse to occur in adolescents and adults, men and women, basic research on drugs of abuse is seldom conducted with age and gender as independent variables. Despite findings that the psychostimulant, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), has neurobiological characteristics typical of drugs that alter the reinforcing efficacy of cocaine, the effects of MDMA on cocaine reinforcement have not been investigated. Thus, the overall aim of the present experiments is to examine the significance of age and gender in the long-term neurobehavioral effects of MDMA. The specific aims are as follows: 1) to record serotonin (5HT) and glutamate depletion in the brain of periadolescent and adult, male and female rats, exposed to MDMA; 2) to test the hypothesis that MDMA will increase the reinforcing effects; and 3) to examine neurotransmission following MDMA pre-exposure by recording behavioral responses to pretreatment with 5HT1B, 5HT2C or dopamine D1 receptor agonists before cocaine self- administration, and neurotransmitter levels in the nucleus accumbens and ventral tegmental area before and during cocaine self-administration. Together the proposed experiments will provide information on age and gender differences in 1) drug-related neurotoxicity and behavioral dysfunction; 2) the long-term effects 5HT dysfunction on the reinforcing properties of cocaine; and 3) the effects of 5HT neurotoxicity on monoaminergic interactions in the mesolimbic system. These investigations may provide insight into the etiology of stimulant dependence and may lead to novel pharmacotherapies for psychostimulant addiction.

尽管药物滥用的社会趋势发生在青少年和