权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

OPTICAL IMAGING OF ODOR CODING IN THE OLFACTORY BULB

嗅球中气味编码的光学成像

基本信息

批准号：
6379243
负责人：
DALE M WACHOWIAK
金额：
$ 1.87万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-04-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/6379243
关键词：
Chelonia behavior test behavioral /social science research tag bioimaging /biomedical imaging digital imaging imaging /visualization /scanning neural information processing odors olfactions olfactory lobe olfactory stimulus perception sensory discrimination

项目摘要

DESCRIPTION: (From Investigator's Abstract) The olfactory bulb is the first synaptic relay in the olfactory pathway, and its function is critical to the detection and discrimination of odors. Loss of normal olfactory function has been associated with nutritional deficits, among other health concerns. In addition, the olfactory bulb is a promising model for understanding sensory processing and perception by the brain. The proposed research will investigate the patterns of neural activity responsible for encoding odor information in the brain. The specific aims of this research are to understand the importance of coherent, odor-evoked oscillations of olfactory bulb activity in odor discrimination, the neural basis for these oscillations, and the relationship between odor-evoked oscillations and a separate, spatial code for representing odor information at the level of the olfactory bulb. The study will use optical imaging with activity-dependent dyes in order to characterize the temporal and spatial patterns of activity in the intact, in vivo olfactory bulb of the turtle. Experiments are proposed to address the temporal and spatial representation of odors by specific populations of olfactory bulb neurons and to test the role of oscillations in mediating odor discrimination at the behavioral level. This work will help elucidate how the olfactory bulb represents odor information and what parameters of olfactory bulb activity are important for discriminating odors.

描述：（摘自研究者摘要）嗅球是嗅觉通路中的第一个突触中继，其功能是对于气味的检测和辨别至关重要。失去正常嗅觉功能与营养缺乏有关，其中其他健康问题。此外，嗅球是一种很有前途的用于理解大脑的感觉处理和感知的模型。拟议的研究将调查神经活动的模式负责在大脑中编码气味信息。具体的这项研究的目的是了解连贯的重要性，气味中嗅球活动的气味引起的振荡辨别力，这些振荡的神经基础，以及气味诱发的振荡与单独的空间之间的关系代表嗅觉层面气味信息的代码电灯泡。该研究将使用活性依赖性染料的光学成像为了描述活动的时间和空间模式在海龟体内完整的嗅球中。实验是建议通过以下方式解决气味的时间和空间表征嗅球神经元的特定群体并测试其作用在行为层面调节气味辨别的振荡。这项工作将有助于阐明嗅球如何代表气味信息以及嗅球活动的哪些参数很重要用于辨别气味。