WIH/Brown Epidemiology/Clinical Trials Training Program

描述（申请人摘要）：WIH/Brown流行病学/临床试验培训计划的目标是为对避孕和生殖健康研究感兴趣的临床训练的妇产科医生提供2-3年的流行病学、生物统计学和临床试验方面的教育。培训方案将通过实现以下目标来实现这一目标：1)为每位研究员提供流行病学、研究设计、统计方法、临床试验、性别问题、研究行为、科学出版、拨款写作等核心课程，以及成为一名成功的生殖健康研究者所需的其他工具；2)为每位研究员提供妇产科和社区卫生方面的导师；这些人将提供指导和专业知识，以确保成功的学术发展；3)提供有利于避孕与生殖健康调查的研究基础设施和支持性环境。该项目将利用布朗大学社区卫生系、妇女健康研究部、布朗大学医学院妇产学系乔治·安德森结果测量组和国家围产期信息中心（NPIC）的现有优势。可供研究员使用的正在进行的研究项目包括：1)PROTECT项目（避孕咨询方法的随机临床试验（RCT），以防止性传播疾病和意外怀孕）；2)功能失调性子宫出血手术治疗结果项目(STOP-DUB) - RCT；3)妇女健康倡议——随机对照试验和观察；4)高血糖与不良妊娠结局研究(HAPO) - RCT；5)妊娠早期和晚期非整倍体风险评估（FASTER）研究- RCT。除了流行病学、生物统计学和性别问题和学术发展方面的核心研讨会的教学工作外，研究员还必须完成至少一项避孕或生殖健康领域的指导独立研究，包括流行病学研究或临床试验的设计、实施和分析。这个多学科项目将提供一个新的妇产科研究骨干，他们将进一步完善生殖健康方面的科学数据库。

DESCRIPTION (Applicant's Abstract): The goal of the WIH/Brown Epidemiology/Clinical Trials Training Program is to provide a 2-3 year period of education in epidemiology, biostatistics, and clinical trials to clinically-trained obstetrician-gynecologists who are interested in contraceptive and reproductive health research. The training program will achieve this goal by accomplishing the following objectives: 1) provide each fellow with a core curriculum in epidemiology, research design, statistical methods, clinical trials, gender issues, conduct of research, scientific publishing, grant writing, and additional tools necessary to become a successful investigator in reproductive health; 2) provide each fellow with a mentor in both Obstetrics and Gynecology and Community Health; these individuals will provide the guidance and expertise to assure successful academic development; 3) provide the research infrastructure and supportive environment conducive to investigation into contraception and reproductive health. The Program will take advantage of the existing strengths of the Department of Community Health at Brown University, the Division of Research in Women's Health and the George Anderson Outcomes Measurement Unit in the Department of Obstetrics and Gynecology, Brown University School of Medicine, and the National Perinatal Information Center (NPIC). Examples of on-going research projects available to fellows include: 1) Project PROTECT (randomized clinical trial (RCT) of contraceptive counseling approaches to prevent sexually transmitted diseases and unplanned pregnancies); 2) Surgical Treatment Outcomes Project for Dysfunctional Uterine Bleeding (STOP-DUB) - RCT; 3) Women's Health Initiative - RCT and observational; 4) Hyperglycemia and Adverse Pregnancy Outcomes Study (HAPO) - RCT; 5) First and 2nd Trimester Evaluation of Risk of Aneuploidy (FASTER) Study- RCT. In addition to didactic course work in epidemiology, biostatistics, and core seminars in gender issues and academic development, fellows must also complete at least one mentored independent study in the area of contraception or reproductive health including the design, conduct and analysis of an epidemiologic study or clinical trial. This multidisciplinary program will provide a new cadre of ob/gyn investigators who will further the scientific database in reproductive health.