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ENZYME LIGAND INTERACTIONS: P CARNII & AIDS

ENZYME LIGAND INTERACTIONS: P CARNII & AIDS
酶配体相互作用:P CARNII
批准号:
6456734
负责人:
TERI Ellen KLEIN
金额:
$27.32万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-07-01 至 2003-08-31

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项目成果

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中文摘要
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英文摘要
We have completed a study comparing different inhibitors including benzylpyrimindines and triazines with many different species of dihydrofolate reductase. This study included enzyme assays in in vivo testing. By comparing Quantitative Structure-Activity Relations with molecular models, we have been able to gain valuable insight into species specificity. We are currently expanding this work to on dihydrofolate reductase to P. Carnii, the causative agent of pneumonia in AIDS patients.
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Pacific Symposium on Biocomputing
  • 批准号:
    10470675
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2021
  • 负责人:
    TERI Ellen KLEIN
  • 依托单位:
Pacific Symposium on Biocomputing
  • 批准号:
    10523536
  • 项目类别:
  • 资助金额:
    $2.0万
  • 财政年份:
    2021
  • 负责人:
    TERI Ellen KLEIN
  • 依托单位:
Pacific Symposium on Biocomputing
  • 批准号:
    10472761
  • 项目类别:
  • 资助金额:
    $2.0万
  • 财政年份:
    2021
  • 负责人:
    TERI Ellen KLEIN
  • 依托单位:
PharmGKB
  • 批准号:
    10555356
  • 项目类别:
  • 资助金额:
    $150.0万
  • 财政年份:
    2020
  • 负责人:
    TERI Ellen KLEIN
  • 依托单位:
海外基金