HYDROGEN BOND MEDIATED NUCLEIC ACID BASE INTERACTIONS

氢键介导的核酸碱基相互作用

• 批准号: 6456745
• 负责人: AENOCH J LYNN
• 金额: $ 27.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6456745
• 关键词: biomedical resource; biotechnology; drug /agent; infection; parasitism; proteins

Libraries of nucleic acid bases hydrogen bonding to each other have been calculated using purely geometric constraints. Libraries have also been calculated for single amino acids hydrogen bonding with nucleic acid bases. These libraries are too large for an individual to browse through, so I am writing an interface to these libraries. I have chosen a web-interface using the Chime plugin from MDLI and Netscape Navigator to display 3-dimensional molecular models. The interface allows users to browse through the library and to identify hydrogen bond interactions in known pdb structure files. Computer Graphics Laboratory resources have been used to retrieve pdb files and to display the structure files using MidasPlus. MidasPlus has also been used to overlap elements from the libraries to see how C1' bonds overlap between various hydrogen bonded structures.

彼此氢键结合的核酸碱基文库 都是用纯粹的几何约束计算出来的 图书馆 还计算了单个氨基酸的氢键， 核酸碱基 这些图书馆对个人来说太大了 所以我正在为这些库编写一个接口。 我 我选择了一个使用MDLI的Chime插件的Web界面， Netscape Navigator显示三维分子模型。 的 界面允许用户浏览库并识别 已知PDB结构文件中氢键相互作用。 计算机 Graphics Laboratory资源已用于检索PDB文件， 使用MidasPlus显示结构文件。 MidasPlus还 用于重叠库中的元素，以查看C1'键合 各种氢键结构之间的重叠。