Conference: 2023 Chloroplast Biotechnology GRC & GRS: Harnessing the SynBio Revolution for Metabolic Engineering and Enhanced Photosynthesis

会议：2023年叶绿体生物技术GRC

• 批准号: 2243932
• 负责人: Klaas van Wijk
• 金额: $ 1.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2243932&HistoricalAwards=false
• 关键词: Conference; 2023; Chloroplast; Biotechnology; GRC

This NSF award will provide financial support to US-based graduate students, postdocs or non-tenured faculty to attend the Gordon Research Conference on Plastid Biotechnology to be held in March 2023, in Ventura, CA, USA. Plastids are essential organelles in algae and plants, and they carry out photosynthesis to produce sugars and starch from captured sunlight and CO2. Plastids also produce a diverse array of molecules that are essential in our food and for our health, including several (pro)vitamins, amino acids, antioxidants, fatty acids and lipids This conference will serve to discuss ongoing research to improve plastids in plants and algae to enhance their production of products that are beneficial for our society. These include vaccines, novel pharmaceutical products, nutritional supplements, as well as biofuels. Junior and senior researchers will discuss and interact to generate new ideas and start novel collaborations to accelerate scientific discoveries.This NSF award will support the Gordon Research Conference on Plastid Biotechnology to be held in March 2023, in Ventura, CA, USA. The conference will present novel research in engineering plastids to either improve existing functions (e.g., photosynthesis) or provide them with new one. Recent progress in this research, particularly through the transfer of molecular solutions from algae and cyanobacteria, has been impressive. In parallel, the engineering of novel functions into chloroplasts to make use of their metabolic and protein synthesis capabilities is also at an exciting juncture. The genetic transformation of plastids is now routine in many plants and algae, so the focus is moving to synthetic biology solutions based on expression of multiple genes under sophisticated control circuits. Indeed, the relatively small and well-understood plastid genome is now a prime target for ambitious projects in several countries aimed at design and synthesis of novel genomes with enhanced traits. The basic science underpinning these advances (e.g., genome structure and replication, control of gene expression, proteostasis, plastid metabolism, metabolite transport) will be covered where relevant to these biotechnological applications. The technologies discussed will cover the entire range from subtle tweaks in plastid metabolism to complete redesign of the plastid genome, and will include all aspects of modifying organellar genomes, proteomes or metabolomes needed for applications in agriculture, industrial biotechnology or the pharmaceutical sector. Target products to be covered include, for example, biopharmaceuticals (vaccines and therapeutic proteins), industrial enzymes, green chemicals and next-generation biofuels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该NSF奖项将为美国研究生，博士后或非终身教职人员提供财政支持，以参加将于2023年3月在美国加利福尼亚州文图拉举行的戈登质体生物技术研究会议。质体是藻类和植物中必不可少的细胞器，它们进行光合作用，从捕获的阳光和CO2中产生糖和淀粉。 质体还产生各种各样的分子，这些分子在我们的食物和我们的健康中是必不可少的，包括几种（前）维生素，氨基酸，抗氧化剂，脂肪酸和脂质。这些包括疫苗、新型药品、营养补充剂以及生物燃料。 初级和高级研究人员将进行讨论和互动，以产生新的想法，并开始新的合作，以加速科学发现。该NSF奖项将支持将于2023年3月在美国加利福尼亚州文图拉举行的戈登质体生物技术研究会议。会议将介绍工程质体的新研究，以改善现有的功能（例如，光合作用）或为它们提供新的。这项研究的最新进展，特别是通过从藻类和蓝藻分子溶液的转移，已经给人留下了深刻的印象。与此同时，利用叶绿体的代谢和蛋白质合成能力将新功能工程化到叶绿体中也处于令人兴奋的时刻。质体的遗传转化现在在许多植物和藻类中是常规的，因此重点正在转向基于复杂控制电路下多个基因表达的合成生物学解决方案。事实上，相对较小且被充分理解的质体基因组现在是几个国家雄心勃勃的项目的主要目标，这些项目旨在设计和合成具有增强性状的新型基因组。支撑这些进步的基础科学（例如，基因组结构和复制、基因表达的控制、蛋白质稳定、质体代谢、代谢物运输）将在与这些生物技术应用相关的地方进行讨论。所讨论的技术将涵盖从质体代谢的细微调整到质体基因组的完全重新设计的整个范围，并将包括农业，工业生物技术或制药部门应用所需的修改细胞器基因组，蛋白质组或代谢组的所有方面。目标产品包括生物制药（疫苗和治疗性蛋白质）、工业酶、绿色化学品和下一代生物燃料。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。