XRAY CRYSTALLOGRAPHIC STUDY OF THETA CLASS GLUTATHIONE S TRANSFERASE

谷胱甘肽S转移酶(GSTs)是一种解毒酶 修饰和溶解亲电毒素。这些酶能去除 血液中的致癌物质，并参与 一些治疗药物的分解。因此，他们可以在 癌症预防和药物输送。到目前为止，研究人员已经失败了 来结晶哺乳动物的theta类GST。我们已经成功地 从大鼠肝脏中结晶出theta类GST 12-12。由于 这些独一无二的晶体对辐射的极端敏感性 同步辐射和晶体冷却可能会极大地 改进可以从它们生成的数据。

Glutathione S-transferases (GSTs) are detoxification enzymes which modify and solubilize electrophilic toxins. These enzymes remove carcinogenic substances from the bloodstream and are involved in the breakdown of some therapeutic drugs. Thus they can play a role in cancer prevention and drug delivery. So far, researchers have failed to crystallize a mammalian theta class GST. We have succeeded in crystallizing the theta class GST 12-12 from rat liver. Due to the extreme radiation sensitivity of these unique crystals, a combination of synchrotron radiation and crystal cooling are likely to greatly improve the data that can be generated from them.