XRAY CRYSTALLOGRAPHIC STUDY OF THETA CLASS GLUTATHIONE S TRANSFERASE

谷胱甘肽S-转移酶（GST）是解毒酶， 修饰和溶解亲电毒素。 这些酶可以去除 血液中的致癌物质，并参与 一些治疗药物的分解。 因此，他们可以发挥作用， 癌症预防和药物输送。 到目前为止，研究人员未能 使哺乳动物的θ类GST结晶 我们成功地 从大鼠肝脏中结晶θ类GST 12-12。 由于 这些独特晶体的极端辐射敏感性， 同步辐射和晶体冷却的技术可能会大大 改进可以从中生成的数据。

Glutathione S-transferases (GSTs) are detoxification enzymes which modify and solubilize electrophilic toxins. These enzymes remove carcinogenic substances from the bloodstream and are involved in the breakdown of some therapeutic drugs. Thus they can play a role in cancer prevention and drug delivery. So far, researchers have failed to crystallize a mammalian theta class GST. We have succeeded in crystallizing the theta class GST 12-12 from rat liver. Due to the extreme radiation sensitivity of these unique crystals, a combination of synchrotron radiation and crystal cooling are likely to greatly improve the data that can be generated from them.