STRUCTURE OF ENZYME SUBSTRATE COMPLEX FOR GENERATION OF UDP N ACETYLMURAMIC ACID
STRUCTURE OF ENZYME SUBSTRATE COMPLEX FOR GENERATION OF UDP N ACETYLMURAMIC ACID
批准号:
6437582
负责人:
JAMES M HOGLE
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-03-01 至 2002-02-28
中文摘要
UDP-N-乙酰丙酮基氨基葡萄糖还原酶(MurB)是一种
在细菌的肽聚糖生物合成途径中。它是
负责承诺的第二个步骤,即减少
烯醇丙酮基-UDP-N-乙酰氨基葡萄糖(EP-UDPGlcNAc)
UDP-N-乙酰壁酸(UDPMurNAc)被NADPH通过紧密结合
黄素腺嘌呤二核苷酸辅因子。由此产生的糖就是
添加五种氨基酸的基础包括
肽链,随后将与N-乙酰氨基葡萄糖相连
形成重复的二糖-五肽亚单位。因为.
该酶在合成肽多糖过程中的本质
为了保持渗透完整性,这种酶是一种新的药物靶点
新型抗菌剂的设计。
英文摘要
UDP-N-acetylenolpyruvylglucosamine reductase (MurB) is an enzyme
in the peptidoglycan biosynthetic pathway of bacteria. It is
responsible for the second committed step, namely the reduction of
enolpyruvyl-UDP-N-acetylglucosamine (EP-UDPGlcNAc) to
UDP-N-acetylmurammic acid (UDPMurNAc) by NADPH via a tightly bound
flavin adenine dinucleotide cofactor. This resulting sugar is then
the foundation for the addition of the five amino acids comprising the
peptide chain and subsequently will be linked with N-acetylglucosamine
to form the repeating disaccharide-pentapeptide subunit. Because of
the essential nature of this enzyme in the synthesis of peptidoglycan
to maintain osmotic integrity, this enzyme is a novel drug target for
design of new antibacterial agents.
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