STRUCTURE OF ENZYME SUBSTRATE COMPLEX FOR GENERATION OF UDP N ACETYLMURAMIC ACID
STRUCTURE OF ENZYME SUBSTRATE COMPLEX FOR GENERATION OF UDP N ACETYLMURAMIC ACID
批准号:
6437582
负责人:
JAMES M HOGLE
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-03-01 至 2002-02-28
中文摘要
UDP-N-乙炔基葡萄糖胺还原酶(MurB)是一种酶,
在细菌的肽聚糖生物合成途径中。 是
负责第二个承诺的步骤,即减少
烯醇化酰基-UDP-N-乙酰葡糖胺(EP-UDPGlcNAc),
NADPH通过紧密结合的UDP-N-乙酰胞壁酸(UDPMurNAc)
黄素腺嘌呤二核苷酸辅因子。 这种糖是
添加组成蛋白质的五种氨基酸的基础
肽链,随后将与N-乙酰葡糖胺连接
以形成重复的二硫键肽-五肽亚基。 因为
这种酶在肽聚糖合成中的基本性质
为了保持渗透完整性,这种酶是一种新的药物靶点,
设计新的抗菌剂。
英文摘要
UDP-N-acetylenolpyruvylglucosamine reductase (MurB) is an enzyme
in the peptidoglycan biosynthetic pathway of bacteria. It is
responsible for the second committed step, namely the reduction of
enolpyruvyl-UDP-N-acetylglucosamine (EP-UDPGlcNAc) to
UDP-N-acetylmurammic acid (UDPMurNAc) by NADPH via a tightly bound
flavin adenine dinucleotide cofactor. This resulting sugar is then
the foundation for the addition of the five amino acids comprising the
peptide chain and subsequently will be linked with N-acetylglucosamine
to form the repeating disaccharide-pentapeptide subunit. Because of
the essential nature of this enzyme in the synthesis of peptidoglycan
to maintain osmotic integrity, this enzyme is a novel drug target for
design of new antibacterial agents.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Correlative cryo-microscopy: a new approach for characterizing the structure and
-
批准号:7904951
-
项目类别:
-
资助金额:$33.56万
-
财政年份:2008
-
负责人:JAMES M HOGLE
-
依托单位:
Correlative cryo-microscopy: a new approach for characterizing the structure and
-
批准号:8118885
-
项目类别:
-
资助金额:$33.23万
-
财政年份:2008
-
负责人:JAMES M HOGLE
-
依托单位:
Correlative cryo-microscopy: a new approach for characterizing the structure and
-
批准号:7514762
-
项目类别:
-
资助金额:$33.81万
-
财政年份:2008
-
负责人:JAMES M HOGLE
-
依托单位:
Correlative cryo-microscopy: a new approach for characterizing the structure and
-
批准号:7664279
-
项目类别:
-
资助金额:$33.9万
-
财政年份:2008
-
负责人:JAMES M HOGLE
-
依托单位:
Structual Analysis of Enterovirus Cell Entry Pathways
-
批准号:6437171
-
项目类别:
-
资助金额:$25.84万
-
财政年份:2002
-
负责人:JAMES M HOGLE
-
依托单位:
MACCHESS CONSORTIUM FOR LARGE MACROMOLECULAR STRUCTURES: HERPES VIRUS
-
批准号:6667800
-
项目类别:
-
资助金额:$14.27万
-
财政年份:2002
-
负责人:JAMES M HOGLE
-
依托单位:
STRUCTURE OF ENZYME SUBSTRATE COMPLEX FOR GENERATION OF UDP N ACETYLMURAMIC ACID
-
批准号:6586664
-
项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:JAMES M HOGLE
-
依托单位:
STRUCTURE OF ENZYME SUBSTRATE COMPLEX FOR GENERATION OF UDP N ACETYLMURAMIC ACID
-
批准号:6658631
-
项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:JAMES M HOGLE
-
依托单位:
MACCHESS CONSORTIUM FOR LARGE MACROMOLECULAR STRUCTURES: HERPES VIRUS
-
批准号:6491123
-
项目类别:
-
资助金额:$14.27万
-
财政年份:2001
-
负责人:JAMES M HOGLE
-
依托单位:
MACCHESS CONSORTIUM FOR LARGE MACROMOLECULAR STRUCTURES: HERPES VIRUS
-
批准号:6339135
-
项目类别:
-
资助金额:$2.6万
-
财政年份:2000
-
负责人:JAMES M HOGLE
-
依托单位:
MACCHESS CONSORTIUM FOR LARGE MACROMOLECULAR STRUCTURES: HERPES VIRUS
-
批准号:6220495
-
项目类别:
-
资助金额:$2.6万
-
财政年份:1999
-
负责人:JAMES M HOGLE
-
依托单位:
STRUCTURE OF ENZYME SUBSTRATE COMPLEX FOR GENERATION OF UDP N ACETYLMURAMIC ACID
-
批准号:6250712
-
项目类别:
-
资助金额:$0.42万
-
财政年份:1997
-
负责人:JAMES M HOGLE
-
依托单位:
SHARED NMR/X-RAY CRYSTALLOGRAPHY SUPERCOMPUTER FACILITY
-
批准号:3521659
-
项目类别:
-
资助金额:$30.0万
-
财政年份:1992
-
负责人:JAMES M HOGLE
-
依托单位:
MOLECULAR AND STRUCTURAL APPROACHES TO ANTIVIRALS
-
批准号:6088735
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1991
-
负责人:JAMES M HOGLE
-
依托单位:
POLIOVIRUS AS A MODEL FOR THE DESIGN OF ANTIVIRAL DRUGS
-
批准号:3547965
-
项目类别:
-
资助金额:$29.51万
-
财政年份:1991
-
负责人:JAMES M HOGLE
-
依托单位:
POLIOVIRUS AS A MODEL FOR THE DESIGN OF ANTIVIRAL DRUGS
-
批准号:3547964
-
项目类别:
-
资助金额:$28.39万
-
财政年份:1991
-
负责人:JAMES M HOGLE
-
依托单位:
MOLECULAR AND STRUCTURAL APPROACHES TO ANTIVIRALS
-
批准号:2067368
-
项目类别:
-
资助金额:$29.3万
-
财政年份:1991
-
负责人:JAMES M HOGLE
-
依托单位:
STRUCTURALLY-BASED COMBINATORIAL DESIGN OF ANTIVIRALS
-
批准号:6708389
-
项目类别:
-
资助金额:$38.7万
-
财政年份:1991
-
负责人:JAMES M HOGLE
-
依托单位:
STRUCTURE OF POLIOVIRUS/ANTIVIRAL DRUG COMPLEXES
-
批准号:3145629
-
项目类别:
-
资助金额:$2.72万
-
财政年份:1991
-
负责人:JAMES M HOGLE
-
依托单位:
SCIENTIFIC REVIEW AND EVALUATION AWARD
-
批准号:6575418
-
项目类别:
-
资助金额:$50.0万
-
财政年份:1991
-
负责人:JAMES M HOGLE
-
依托单位: