COLLABORATIVE PROSPECTIVE STUDY OF VERTICAL TRANSMISSION OF HIV

HIV 垂直传播的合作前瞻性研究

• 批准号: 6441975
• 负责人: Kenneth McIntosh
• 金额: $ 2.88万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6441975
• 关键词: AIDS /HIV diagnosis; AIDS therapy; HIV infections; child (0-11); child physical development; clinical research; disease /disorder proneness /risk; early diagnosis; human subject; human therapy evaluation; longitudinal human study; mother /infant health care; pediatric AIDS; polymerase chain reaction; vertical transmission; virus infection mechanism

Women and Infants Transmission Study (WITS), the purpose of which is to begin to understand how often HIV is passed on to children of risk mothers; to make early diagnosis; to understand how children with HIV infection grow and develop; and to allow early intervention as therapies become available. Currently, 82 infants and children are actively followed in WITS at Children's Hospital. A number of findings over a broad spectrum of disciplines has begun to emerge from the WITS study. The preliminary findings are interesting and may possibly be useful for counseling pregnant women. The following are research areas resulting from WITS: 1) obstetrical factors which influence HIV-1 transmission; 2) immunologic and virologic correlates of vertical transmission; 3) use of dried blood spot specimens and the diagnostic value of PCR for detection of HIV, and 4) natural history of somatic growth in infants born to HIV infected women.

妇女和婴儿传播研究（WITS），其目的是开始了解艾滋病毒传播给风险母亲的孩子的频率；早期诊断；了解感染艾滋病毒的儿童如何生长发育；并允许在治疗可行时进行早期干预。目前，儿童医院的WITS积极跟踪82名婴儿和儿童。WITS的研究已经开始在广泛的学科范围内产生许多发现。初步的发现很有趣，可能对孕妇的咨询有用。以下是WITS的研究领域：1)影响HIV-1传播的产科因素；2)垂直传播的免疫学和病毒学相关性；3)利用干血斑标本及PCR检测HIV的诊断价值；4)HIV感染妇女所生婴儿的躯体生长自然史。