Effects of allergens on dendritic cell function in allergic asthma
过敏原对过敏性哮喘树突状细胞功能的影响
基本信息
- 批准号:nhmrc : 303161
- 负责人:
- 金额:$ 16.95万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:NHMRC Project Grants
- 财政年份:2004
- 资助国家:澳大利亚
- 起止时间:2004-01-01 至 2006-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In recent decades, there has been a nearly three-fold increase in the prevalence of allergic diseases such as asthma. Although the reason these diseases have increased in prevalence remains unknown, we suspect the way in which the immune system responds to foreign proteins in the environment may be very important in determining whether an individual develops allergic disease or not. How and why individuals with allergic asthma respond excessively and inappropriately to inhalation of a small range of seemingly innocuous proteins (allergens) is a central question in respiratory medicine and allergy. We propose that investigating the way that antigen presenting dendritic cells (DC) respond directly to allergens will shed important light on this issue, as DC are fundamental to our ability to deal with foreign antigens and to generate an appropriate immune response. The overall hypothesis underpinning this proposal is that allergens induce specific responses in DC from individuals with allergic asthma, and that this contributes to the maintenance and amplification of allergic tissue inflammation in this disease. Understanding the ways in which DC respond to clinically relevant allergens will lead to significant progress in understanding the pathogenesis of allergic asthma. This project was recommended for funding last year, but was relinquished when one of the previous co-investigators on last year's grant was awarded a Program grant.
近几十年来,哮喘等过敏性疾病的患病率增加了近三倍。尽管这些疾病发病率增加的原因尚不清楚,但我们怀疑免疫系统对环境中外源蛋白的反应方式可能在确定个体是否患上过敏性疾病方面非常重要。过敏性哮喘患者如何以及为什么对吸入少量看似无害的蛋白质(过敏原)产生过度和不适当的反应是呼吸道医学和过敏的中心问题。我们建议,调查抗原呈递树突状细胞(DC)直接响应过敏原的方式将为这个问题提供重要的启示,因为DC是我们处理外来抗原和产生适当免疫反应的能力的基础。支持这一提议的总体假设是,过敏原诱导过敏性哮喘个体的DC中的特异性反应,并且这有助于维持和放大这种疾病中的过敏性组织炎症。了解DC对临床相关过敏原的反应方式将有助于了解过敏性哮喘的发病机制取得重大进展。该项目去年曾被推荐资助,但当去年赠款的前共同研究者之一获得项目赠款时,该项目被放弃。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Prof Alan James其他文献
Prof Alan James的其他文献
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{{ truncateString('Prof Alan James', 18)}}的其他基金
Mechanisms of airway narrowing in eosinophilic and non-eosinophilic asthma
嗜酸性粒细胞和非嗜酸性粒细胞哮喘气道狭窄的机制
- 批准号:
nhmrc : 618700 - 财政年份:2010
- 资助金额:
$ 16.95万 - 项目类别:
NHMRC Project Grants
Practitioner Fellowship
从业者团契
- 批准号:
nhmrc : 557500 - 财政年份:2009
- 资助金额:
$ 16.95万 - 项目类别:
NHMRC Research Fellowships
THE CHANGING PREVALENCE OF ASTHMA AND CHRONIC OBSTRUCTIVE AIRWAY DISEASE IN AUSTRALIA
澳大利亚哮喘和慢性阻塞性气道疾病患病率的变化
- 批准号:
nhmrc : 353532 - 财政年份:2005
- 资助金额:
$ 16.95万 - 项目类别:
NHMRC Project Grants
Airway inflammation and remodeling
气道炎症和重塑
- 批准号:
nhmrc : 246100 - 财政年份:2003
- 资助金额:
$ 16.95万 - 项目类别:
NHMRC Research Fellowships
Airway inflammation in asthma and chronic obstructive pulmonary disease (COPD)
哮喘和慢性阻塞性肺疾病 (COPD) 中的气道炎症
- 批准号:
nhmrc : 981516 - 财政年份:1998
- 资助金额:
$ 16.95万 - 项目类别:
NHMRC Project Grants
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