Mechanisms of airway narrowing in eosinophilic and non-eosinophilic asthma

嗜酸性粒细胞和非嗜酸性粒细胞哮喘气道狭窄的机制

• 批准号: nhmrc : 618700
• 负责人: Prof Alan James
• 金额: $ 33.38万
• 依托单位: Sir Charles Gairdner Hospital
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-airway-narrowing-eosinophilic-asthma/82656
• 关键词: Mechanisms; airway; narrowing; eosinophilic; non

Asthma is associated with excessive airway narrowing, increased thickness of the airway wall and inflammation, most typically with eosinophils. However, 50% of cases have few eosinophils and respond less well to current treatments. This project will examine differences in airway structure between patients with or without eosinophils, using post-mortem tissue, as part of an international research collaboration.

哮喘与气道过度狭窄、气道壁厚度增加和炎症有关，最典型的是嗜酸性粒细胞。然而，50%的病例嗜酸性粒细胞较少，对目前的治疗反应较差。作为国际研究合作的一部分，该项目将使用死后组织研究嗜酸性粒细胞患者或非嗜酸性粒细胞患者气道结构的差异。