BIOMARKERS OF OSTEOARTHRITIS--THEIR EPIDEMIOLOGY

骨关节炎的生物标志物——其流行病学

• 批准号: 6416835
• 负责人: MARYFRAN R SOWERS
• 金额: $ 11.52万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6416835
• 关键词: biomarker; bone density; bone metabolism; clinical research; diagnosis quality /standard; early diagnosis; epidemiology; female; human subject; musculoskeletal disorder diagnosis; osteoarthritis; radiography

Osteoarthritis (OA) is a highly prevalent chronic disease leading to significant functional limitations in both males and females, but particularly women. We propose to characterize the natural history of osteoarthritis (of the knee and hand) using radiographs, interviews and markers of cartilage and bone turnover as well as joint inflammation with this longitudinal study. The specific questions are: 1.Do biochemical markers of osteoarthritis (OA) provide evidence os OA earlier than radiographs.? 2.Can turnover markers be used to define natural history and progression of arthritis? 3.Are bone mineral density(BMD) loss and development/initiation of OA highly regulated? These questions can be addressed efficiently by concatenating historical data from two previously generated population-based groups. One population(Tecumseh Bone Health Study) of 573 women was 25-45 years at their 1992 baseline evaluation (R01-AR-40888--Bone Mineral Density Change and the Climacteric). Hand and knee films were taken two times four years apart (1992 and 1996) along with an annual BMD measurement. Annual urine and serum specimens were collected and are available for analysis of OA markers. The second group, from the SWAN Study (NR-04061), is a population-based group of 300 African-American and 150 Caucasian pre and perimenopausal women, aged 42-52 years at their 1996 baseline when hand and knee films were characterized and serum and urine collected. To the retrospectively available data, we propose to recontract these 1,023 women for radiographs (hand and knee) and interviews in 1998 and 2000 and add annual blood and urine collection with identification of potential markers of arthritis (including turnover on bone/collagen and inflammation). This would allow the examination of the initiation of osteoarthritis using radiographs, interviews and turnover biomarkers. This information about the natural history of osteoarthritis should allow us to consider more appropriate prevention and intervention strategies and offer the potential to identify markers prognostic of disease incidence and of processes involved in its pathobiology.

骨关节炎（OA）是一种高度流行的慢性疾病， 男性和女性都有明显的功能限制，但 尤其是女性。我们建议描述自然历史的特征， 骨关节炎（膝关节和手）使用X光片，访谈和 软骨和骨转换以及关节炎的标志物， 这项纵向研究。具体问题如下： 1.骨关节炎（OA）的生化标志物是否提供了骨关节炎（OA）的证据？ OA早于X光片。 2.周转标志物是否可以用来定义自然历史， 关节炎的进展？ 3.骨矿物质密度（BMD）损失和发展/开始 高度规范的？ 这些问题可以通过以下方式有效解决： 来自两个先前生成的基于人口的组的历史数据。一 573名女性的人群（特库姆塞骨健康研究）为25-45岁， 1992年基线评价（R 01-AR-40888--骨矿物质密度变化 和更年期）。手和膝盖的影像四年拍了两次 除了（1992年和1996年）沿着与每年的BMD测量。年尿 收集血清标本，用于OA分析 标记。第二组，来自SWAN研究（NR-04061），是一个 300名非裔美国人和150名高加索人的人群组， 1996年基线时年龄为42-52岁的围绝经期妇女， 并收集血清和尿液。 根据可追溯的数据，我们建议将这些 1998年，1 023名妇女接受了X光检查（手和膝盖）和面谈， 2000年，并增加了每年的血液和尿液采集， 关节炎的潜在标志物（包括骨/胶原蛋白的转换， 炎症）。这将有助于审查 骨关节炎使用放射照片，访谈和营业额生物标志物。这 关于骨关节炎自然史的信息应该使我们能够 考虑更适当的预防和干预战略， 确定疾病发生率和预后的标志物的潜力 参与其病理生物学的过程。