BIOMARKERS OF OSTEOARTHRITIS--THEIR EPIDEMIOLOGY

骨关节炎(OA)是一种高度流行的慢性疾病，导致 男性和女性都有明显的功能缺陷，但 尤其是女人。我们建议描述一下 骨性关节炎(膝盖和手部)使用X光片、面谈和 软骨和骨转换以及关节炎症的标记物 这项纵向研究。具体问题如下： 1.骨关节炎(OA)的生化指标能提供证据吗？ 骨性关节炎早于X线片。 2.周转标志是否可以用来定义自然历史和 关节炎的进展？ 3.骨密度(BMD)丢失与骨质疏松症的发生 办公自动化受到高度监管？ 通过串联可以有效地解决这些问题 来自之前生成的两个基于人口的群体的历史数据。一 (Tecumseh骨健康研究)573名女性的年龄在25-45岁之间 他们1992年的基线评估(R01-AR-40888--骨密度变化 和更年期)。手部和膝盖的照片拍摄了两次，四年内 分开(1992年和1996年)，并每年进行骨密度测量。年度尿量 并采集血清标本，用于分析骨性关节炎 记号笔。第二组来自天鹅研究(NR-04061)，是一种 由300名非洲裔美国人和150名高加索人组成的以人口为基础的小组 围绝经期妇女，以1996年的基线年龄42-52岁 检查膝关节片，采集血清和尿液。 对于可追溯的数据，我们建议重新签约这些 1998年1,023名妇女接受X光检查(手部和膝盖)和面谈 2000年，并增加每年的血液和尿液采集，以识别 关节炎的潜在标记物(包括骨/胶原蛋白和 炎症)。这将允许对发起 使用X线片、访谈和周转生物标记物诊断骨关节炎。这 有关骨关节炎自然病史的信息应该能让我们 考虑更适当的预防和干预策略，并提供 确定疾病发病率和预后的标志物的可能性 与其病理生物学有关的过程。

Osteoarthritis (OA) is a highly prevalent chronic disease leading to significant functional limitations in both males and females, but particularly women. We propose to characterize the natural history of osteoarthritis (of the knee and hand) using radiographs, interviews and markers of cartilage and bone turnover as well as joint inflammation with this longitudinal study. The specific questions are: 1.Do biochemical markers of osteoarthritis (OA) provide evidence os OA earlier than radiographs.? 2.Can turnover markers be used to define natural history and progression of arthritis? 3.Are bone mineral density(BMD) loss and development/initiation of OA highly regulated? These questions can be addressed efficiently by concatenating historical data from two previously generated population-based groups. One population(Tecumseh Bone Health Study) of 573 women was 25-45 years at their 1992 baseline evaluation (R01-AR-40888--Bone Mineral Density Change and the Climacteric). Hand and knee films were taken two times four years apart (1992 and 1996) along with an annual BMD measurement. Annual urine and serum specimens were collected and are available for analysis of OA markers. The second group, from the SWAN Study (NR-04061), is a population-based group of 300 African-American and 150 Caucasian pre and perimenopausal women, aged 42-52 years at their 1996 baseline when hand and knee films were characterized and serum and urine collected. To the retrospectively available data, we propose to recontract these 1,023 women for radiographs (hand and knee) and interviews in 1998 and 2000 and add annual blood and urine collection with identification of potential markers of arthritis (including turnover on bone/collagen and inflammation). This would allow the examination of the initiation of osteoarthritis using radiographs, interviews and turnover biomarkers. This information about the natural history of osteoarthritis should allow us to consider more appropriate prevention and intervention strategies and offer the potential to identify markers prognostic of disease incidence and of processes involved in its pathobiology.