MRI DETERMINED BONE MARROW EDEMA IN OSTEOARTHRITIS OF THE KNEE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然骨关节炎(OA)非常普遍，包括关节软骨、软骨下骨和滑膜受损，但作为一种症状，疼痛是导致大部分残疾、治疗和医疗费用的原因。对于骨性关节炎疼痛模式如何与关节组织相关的认识非常有限，特别是因为软骨没有感受疼痛所需的神经末梢。然而，更好地了解导致与关节结构有关的痛性骨性关节炎的发展和持久的过程，可能会增加干预的选择数量。这一应用有助于一系列研究，以确定骨性关节炎患者的疼痛是否与骨髓水肿(BME)有关，这一点只能通过磁共振成像(MRI)观察到。据认为，这种“浮肿”或液体堆积增加了关节中骨骼内的压力，并激活了骨骼中的疼痛感受器。进一步提出，BME的部分原因是膝关节上的负重力分布不均，很可能是由肥胖引发或延续的。目前，BME是根据病变大小的3级确定进行定性评估的。我们建议开发一种定量方法来测量BME，并用MRI描述该方法的重复性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Though osteoarthritis (OA) is highly prevalent and includes compromised articular cartilage, subchondral bone, and synovium, pain as a symptom drives much of the disability, requirement for therapy and health care costs. There is a very limited understanding of how OA pain patterns are related to tissue in the joint, particularly since cartilage does not have nerve endings that are required to feel pain. However, a better understanding of the processes leading to the development and perpetuation of painful OA, in relation to joint structures, is likely to extend the number of options for intervention. This application contributes to a series of studies to determine if pain in OA is associated with bone marrow edema (BME), observable only with magnetic resonance imaging (MRI). It is proposed that this "edema" or fluid accumulation increases the pressure within bone in joints and activates pain receptors in the bone. It is further proposed that BME comes, in part, from mal-distributed weight-bearing forces on the knee and is most likely initiated or perpetuated by obesity. Currently, BME is evaluated qualitatively based on a 3-level determination of the size of a lesion. We propose to develop a quantitative approach to measure BME and describe the reproducibility of that approach with MRI.'