MRI DETERMINED BONE MARROW EDEMA IN OSTEOARTHRITIS OF THE KNEE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 虽然骨关节炎（OA）是高度流行的并且包括受损的关节软骨、软骨下骨和滑膜，但是疼痛作为症状驱动大部分残疾、治疗需求和医疗保健成本。关于OA疼痛模式与关节组织的关系，人们的理解非常有限，特别是因为软骨没有感觉疼痛所需的神经末梢。然而，更好地了解导致疼痛性骨关节炎发展和持续的过程，与关节结构有关，可能会增加干预选择的数量。该应用有助于一系列研究，以确定OA疼痛是否与骨髓水肿（BME）相关，只能通过磁共振成像（MRI）观察到。有人提出，这种“水肿”或液体积聚会增加关节内骨骼的压力，并激活骨骼中的疼痛受体。进一步提出，BME部分来自膝关节上分布不均的承重力，并且最有可能由肥胖引发或延续。目前，BME是基于病变大小的3级测定进行定性评价的。我们建议开发一种定量方法来测量BME，并描述该方法与MRI的再现性。'

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Though osteoarthritis (OA) is highly prevalent and includes compromised articular cartilage, subchondral bone, and synovium, pain as a symptom drives much of the disability, requirement for therapy and health care costs. There is a very limited understanding of how OA pain patterns are related to tissue in the joint, particularly since cartilage does not have nerve endings that are required to feel pain. However, a better understanding of the processes leading to the development and perpetuation of painful OA, in relation to joint structures, is likely to extend the number of options for intervention. This application contributes to a series of studies to determine if pain in OA is associated with bone marrow edema (BME), observable only with magnetic resonance imaging (MRI). It is proposed that this "edema" or fluid accumulation increases the pressure within bone in joints and activates pain receptors in the bone. It is further proposed that BME comes, in part, from mal-distributed weight-bearing forces on the knee and is most likely initiated or perpetuated by obesity. Currently, BME is evaluated qualitatively based on a 3-level determination of the size of a lesion. We propose to develop a quantitative approach to measure BME and describe the reproducibility of that approach with MRI.'