The relationship between somatic structural alteration of the genome and healthy ageing
The relationship between somatic structural alteration of the genome and healthy ageing
基因组体细胞结构改变与健康衰老的关系
批准号：
1902605
负责人：
金额：
$0.0万
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2017
资助国家：
英国
项目状态：
已结题
起止时间：
2017 至 --
中文摘要
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英文摘要
It is increasingly clear that somatic mutations accrue steadily in ageing tissues. However, precisely how this relates to healthy ageing is unknown, and the molecular and cellular mechanisms that cause somatic mutation in otherwise healthy tissue remain poorly defined. Here, we propose to investigate the accrual of structural alterations (SAs) in ageing human colon. We will determine the spectrum of SA that is consistent with healthy ageing (e.g. the SAs that can accrue without leading to a pathology), and profile the size, type and rate of SA accrual to reveal the underlying molecular and cellular mechanisms that underpin 'healthy' human somatic mutagenesis.
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DOI：
10.1101/2021.07.14.451265
发表时间：
2021-07
期刊：
bioRxiv
影响因子：
--
作者：
[Timon Heide;J. Househam;George D. Cresswell;I. Spiteri;Claire Lynn;C. Kimberley;M. Mossner;L. Zapata;C. Gabbutt;Daniele Ramazzotti;Bingjie Chen;J. Fernández-Mateos;C. James;A. Vinceti;A. Berner;Melissa Schmidt;E. Lakatos;A. Baker;D. Nichol;Helena Costa;Miriam Mitchinson;B. Werner;F. Iorio;M. Jansen;Chris P. Barnes;G. Caravagna;D. Shibata;J. Bridgewater;M. Rodríguez-Justo;L. Magnani;T. Graham;A. Sottoriva]
通讯作者：
Timon Heide;J. Househam;George D. Cresswell;I. Spiteri;Claire Lynn;C. Kimberley;M. Mossner;L. Zapata;C. Gabbutt;Daniele Ramazzotti;Bingjie Chen;J. Fernández-Mateos;C. James;A. Vinceti;A. Berner;Melissa Schmidt;E. Lakatos;A. Baker;D. Nichol;Helena Costa;Miriam Mitchinson;B. Werner;F. Iorio;M. Jansen;Chris P. Barnes;G. Caravagna;D. Shibata;J. Bridgewater;M. Rodríguez-Justo;L. Magnani;T. Graham;A. Sottoriva
DOI：
10.1101/2023.11.10.23298336
发表时间：
2023-11
期刊：
影响因子：
--
作者：
[C. Gabbutt;M. Duran-Ferrer;H. Grant;D. Mallo;F. Nadeu;J. Househam;N. Villamor;O. Krali]
通讯作者：
C. Gabbutt;M. Duran-Ferrer;H. Grant;D. Mallo;F. Nadeu;J. Househam;N. Villamor;O. Krali
DOI：
10.1038/s41587-021-01109-w
发表时间：
2022-05
期刊：
NATURE BIOTECHNOLOGY
影响因子：
46.9
作者：
[Gabbutt, Calum, Schenck, Ryan O., Weisenberger, Daniel J., Kimberley, Christopher, Berner, Alison, Househam, Jacob, Lakatos, Eszter, Robertson-Tessi, Mark, Martin, Isabel, Patel, Roshani, Clark, Susan K., Latchford, Andrew, Barnes, Chris P., Leedham, Simon J., Anderson, Alexander R. A., Graham, Trevor A., Shibata, Darryl]
通讯作者：
Shibata, Darryl
DOI：
10.1002/path.5911
发表时间：
2022-07
期刊：
The Journal of pathology
影响因子：
--
作者：
[]
通讯作者：
DOI：
10.1038/s41586-022-05311-x
发表时间：
2022-11
期刊：
NATURE
影响因子：
64.8
作者：
[Househam, Jacob, Heide, Timon, Cresswell, George D., Spiteri, Inmaculada, Kimberley, Chris, Zapata, Luis, Lynn, Claire, James, Chela, Mossner, Maximilian, Fernandez-Mateos, Javier, Vinceti, Alessandro, Baker, Ann-Marie, Gabbutt, Calum, Berner, Alison, Schmidt, Melissa, Chen, Bingjie, Lakatos, Eszter, Gunasri, Vinaya, Nichol, Daniel, Costa, Helena, Mitchinson, Miriam, Ramazzotti, Daniele, Werner, Benjamin, Iorio, Francesco, Jansen, Marnix, Caravagna, Giulio, Barnes, Chris P., Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Sottoriva, Andrea, Graham, Trevor A.]
通讯作者：
Graham, Trevor A.
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