Sensory experience and pre-configured networks in developing neural circuits for navigation'

开发导航神经回路时的感官体验和预配置网络”

• 批准号: 1902720
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1902720
• 关键词: Sensory; experience; pre; configured; networks

This project will investigate the post-natal development of the neural map of space in the hippocampus, testing the roles of sensory experience and experience-independent, pre-configured networks in the assembly of neural circuits for navigation. The project will make use of two recently available technologies: 1) wireless technology will be used to conduct neural recordings in natural environments, investigating the role of sensory experience in development, 2) longitudinal 2-photon imaging will be used to track the activity of hippocampal networks before and after they display spatial tuning, testing for the presence of experience independent activity patterns.

该项目将研究海马体中空间神经地图的出生后发育，测试感官体验和经验独立的预配置网络在导航神经回路组装中的作用。该项目将利用两种最近可用的技术：1）无线技术将用于在自然环境中进行神经记录，调查感官体验在发育中的作用，2）纵向双光子成像将用于跟踪海马网络在显示空间调谐之前和之后的活动，测试经验独立活动模式的存在。