Effects of circadian disruption and sleep deprivation in respiratory disorders

昼夜节律紊乱和睡眠剥夺对呼吸系统疾病的影响

• 批准号: nhmrc : 352483
• 负责人: Prof Naomi Rogers
• 金额: $ 27.21万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-circadian-disruption-respiratory-disorders/95510
• 关键词: Effects; circadian; disruption; sleep; deprivation

This project aims to determine the impact of reduced sleep hours and jet lag-sleep time shift in two very common breathing disorders; sleep apnea (snoring sickness) and asthma. We will also make measurements in healthy normal people as well. Reduced sleep hours are common in many sections of society due to a number of factors, including increased work hours, overtime, shiftwork, medical conditions (sleep and other medical disorders), caring for a new baby, and other family and social demands. In addition, body clock disruption due to shiftwork, transmeridien travel, circadian based sleep disorders and other factors that shift the timing of normal sleep-wake behaviour is also very prevalent in today's society. The effects of reduced sleep hours and jet lag-sleep time shift effect a number of body systems but have only been studied to a limited extent in the breathing system. Jet lag-sleep time shift changes are result of changes to the body clock rhythms - these rhythms effect coordinate activities of essentially all bodily functions, vigilance and thinking, heart, breathing, hormones, bowel function and the immune system that fights off infection and cancer. Together, this body clock system and sleep coordinate the majority of systems of the body and brain. This project will address a number of questions including whether reduced sleep hours worsen brain function in sleep apnea or whether shifting sleep (jet lag effect) can worsen airway function and increase risk of asthma. We will use two types of study - simulated jet lag and reduced sleep hours under complete laboratory supervision to test our theories

该项目旨在确定睡眠时间减少和时差-睡眠时间偏移对两种非常常见的呼吸障碍的影响;睡眠呼吸暂停（打鼾疾病）和哮喘。我们还将在健康的正常人中进行测量。由于许多因素，睡眠时间减少在社会的许多部分都很常见，包括工作时间增加，加班，轮班，医疗条件（睡眠和其他医疗疾病），照顾新生儿以及其他家庭和社会需求。此外，由于轮班工作、跨昼夜旅行、基于昼夜节律的睡眠障碍和改变正常睡眠-觉醒行为的时间的其他因素而导致的生物钟中断在当今社会中也非常普遍。睡眠时间减少和喷射滞后睡眠时间偏移的影响影响了许多身体系统，但在呼吸系统中仅进行了有限程度的研究。时差-睡眠时移变化是生物钟节律变化的结果-这些节律影响基本上所有身体功能的协调活动，警惕和思考，心脏，呼吸，激素，肠道功能和抵抗感染和癌症的免疫系统。这种生物钟系统和睡眠共同协调身体和大脑的大部分系统。该项目将解决一系列问题，包括睡眠时间减少是否会使睡眠呼吸暂停的大脑功能恶化，或者改变睡眠（时差效应）是否会使气道功能恶化并增加哮喘的风险。我们将使用两种类型的研究-模拟时差和减少睡眠时间在完全实验室监督下，以测试我们的理论