Structural imaging /neuroanatomy research unit

结构成像/神经解剖学研究单位

• 批准号: 6488263
• 负责人: NANCY C ANDREASEN
• 金额: $ 26.64万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6488263
• 关键词: autism; bioimaging /biomedical imaging; brain imaging /visualization /scanning; cognition; hippocampus; human data; magnetic resonance imaging; memory; neuroanatomy; neurologic manifestations; neuropathology; neurophysiology; schizophrenia

Overall aims 1. To use MR to identify and study the neuroanatomic abnormalities that occur in disease states, such as schizophrenia or autism. 2. To use MR to examine neuroanatomic measures that may provide information about neurodevelopmental processes, such as gyrification patterns. 3. To use MR to study and measure specific subregions, hypothesized to be involved in dysfunctional anatomic/functional circuitry in schizophrenia, such as prefrontal cortex, thalamus, and cerebellum. 4. To use MR to examine anatomic circuitry directly through the use of diffusion anisotropy. 5. To use MR to study factors that could confound measurements of brain structure in schizophrenia, such as hydrational status. 6. To identify and develop new methods that will facilitate these aims, such as novel scanning sequences or new approaches to image analysis (e.g., neural nets, global pattern matching). 7. To confirm MR findings and improve their spatial resolution through the study of postmortem tissue.

总体目标1。使用MR来识别和研究在疾病状态下发生的神经解剖学异常，如精神分裂症或自闭症。2.使用MR检查神经解剖学测量，可以提供有关神经发育过程的信息，如脑回模式。3.使用MR研究和测量特定的亚区域，假设这些亚区域参与精神分裂症中功能障碍的解剖/功能回路，如前额叶皮层、丘脑和小脑。4.通过使用扩散各向异性，使用MR直接检查解剖电路。5.使用MR研究可能混淆精神分裂症患者脑结构测量的因素，如水合状态。6.确定和开发有助于实现这些目标的新方法，例如新的扫描序列或新的图像分析方法（例如，神经网络、全局模式匹配）。7.通过对尸体组织的研究，证实MR所见，提高其空间分辨率。