Structural imaging /neuroanatomy research unit

总体目标使用磁共振识别和研究在疾病状态下发生的神经解剖学异常，如精神分裂症或自闭症。2. 利用核磁共振检查神经解剖学指标，提供有关神经发育过程的信息，如旋转模式。3. 使用MR研究和测量特定的亚区，假设与精神分裂症中功能失调的解剖/功能电路有关，如前额叶皮质、丘脑和小脑。4. 利用磁共振通过扩散各向异性直接检查解剖电路。5. 利用核磁共振研究可能混淆精神分裂症患者大脑结构测量的因素，如水合状态。6. 确定和开发有助于实现这些目标的新方法，例如新的扫描序列或图像分析的新方法（例如，神经网络，全局模式匹配）。7. 通过对死后组织的研究，确认MR发现并提高其空间分辨率。

Overall aims 1. To use MR to identify and study the neuroanatomic abnormalities that occur in disease states, such as schizophrenia or autism. 2. To use MR to examine neuroanatomic measures that may provide information about neurodevelopmental processes, such as gyrification patterns. 3. To use MR to study and measure specific subregions, hypothesized to be involved in dysfunctional anatomic/functional circuitry in schizophrenia, such as prefrontal cortex, thalamus, and cerebellum. 4. To use MR to examine anatomic circuitry directly through the use of diffusion anisotropy. 5. To use MR to study factors that could confound measurements of brain structure in schizophrenia, such as hydrational status. 6. To identify and develop new methods that will facilitate these aims, such as novel scanning sequences or new approaches to image analysis (e.g., neural nets, global pattern matching). 7. To confirm MR findings and improve their spatial resolution through the study of postmortem tissue.