Structural imaging /neuroanatomy research unit

总体目标1。使用磁共振来识别和研究在疾病状态下发生的神经解剖异常，如精神分裂症或自闭症。2.使用MR检查神经解剖学测量，这些测量可能提供有关神经发育过程的信息，如脑回模式。3.利用磁共振研究和测量假设参与精神分裂症解剖/功能回路功能障碍的特定亚区，如前额叶皮质、丘脑和小脑。4.利用弥散各向异性，直接用磁共振检查解剖回路。5.使用磁共振来研究精神分裂症患者大脑结构测量的混乱因素，如水合状态。6.确定和开发有助于实现这些目标的新方法，例如新的扫描序列或图像分析的新方法(例如，神经网络、全局模式匹配)。7.通过对身体组织的研究，证实MR表现并提高其空间分辨率。

Overall aims 1. To use MR to identify and study the neuroanatomic abnormalities that occur in disease states, such as schizophrenia or autism. 2. To use MR to examine neuroanatomic measures that may provide information about neurodevelopmental processes, such as gyrification patterns. 3. To use MR to study and measure specific subregions, hypothesized to be involved in dysfunctional anatomic/functional circuitry in schizophrenia, such as prefrontal cortex, thalamus, and cerebellum. 4. To use MR to examine anatomic circuitry directly through the use of diffusion anisotropy. 5. To use MR to study factors that could confound measurements of brain structure in schizophrenia, such as hydrational status. 6. To identify and develop new methods that will facilitate these aims, such as novel scanning sequences or new approaches to image analysis (e.g., neural nets, global pattern matching). 7. To confirm MR findings and improve their spatial resolution through the study of postmortem tissue.