UAB MENTAL RETARDATION RESEARCH CENTER (MRRC)

UAB 智力低下研究中心 (MRRC)

• 批准号: 6387734
• 负责人: MICHAEL J FRIEDLANDER
• 金额: $ 64.29万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-04 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6387734
• 关键词: biomedical facility; mental retardation

The Mental Retardation Research Center (MRRC) at the University of Alabama at Birmingham (UAB) builds upon UAB's contributions over the past 3 decades to the field of mental retardation and developmental disabilities (MR/DD). The MRRC's mission is threefold: to increase scientific knowledge preventative interventions for MR/DD; and to advance understanding about effective treatment strategies to ameliorate the personnel, familial, and societal consequence of MR/DD. Forty-two investigations from 14 basic science and clinical departments (with 90 funded or pending research projects that will use core supports) will participate. The 6 major Research Groups are: I. Functional synaptic development and plasticity; II. Molecular biology/genetics of nervous system development; III. Neuroendocrinology and infectious disease, IV. Risk conditions and early interventions, V. Low birthweight and prematurity, and VI. Learning, memory, and intelligence. An Administration and Communications Core Unit (Core A) provides scientific leadership, sponsors center-wide scientific seminars and colloquia, encourages innovation and new multi-disciplinary collaborations, actively mentors junior MRRC investigators, and oversees administrative functioning. The four Research Cores are: the Recombinant Technologies Core (Core B), the Simultaneous Laser Scanning Imaging and Electrophysiology Core (Core C), the Longitudinal Studies and Statistical Modeling Core (Core D), and the Developmental Neurobiology Imaging and Tissue Processing Core (Core E). Individually and collectively, these cores are designed to promote multi-disciplinary collaboration, timely exchange of information and technology advances, attract new investigators to MR/DD research, and promote research activities with other MRRCs, as well as to increase the quality and productivity of funded research projects while demonstrating cost- effectiveness. Of high priority is the inclusion of women and individual from under-represented ethnic/racial groups as MRRC scientists, trainees, and participants in research projects.

阿拉巴马大学伯明翰分校（UAB）的智力发育迟缓研究中心（MRRC）建立在UAB过去30年在智力发育迟缓和发育障碍（MR/DD）领域的贡献基础上。MRRC的使命有三个方面：增加对MR/DD的科学知识和预防性干预措施；并促进对有效治疗策略的理解，以改善MR/DD对个人、家庭和社会的影响。来自14个基础科学和临床科室的42项研究（其中90个已资助或正在进行的研究项目将使用核心支持）将参与。6个主要研究小组：1 .功能性突触发育与可塑性；2。神经系统发育的分子生物学/遗传学；3。神经内分泌学和传染病，IV.风险条件和早期干预，V.低出生体重和早产，以及VI.学习，记忆和智力。行政和通信核心单位（核心A）提供科学领导，赞助中心范围的科学研讨会和座谈会，鼓励创新和新的多学科合作，积极指导MRRC的初级研究人员，并监督行政职能。四个研究核心是：重组技术核心（Core B），同步激光扫描成像和电生理学核心（Core C），纵向研究和统计建模核心（Core D），以及发育神经生物学成像和组织处理核心（Core E）。这些核心的目的是促进多学科合作，及时交流信息和技术进步，吸引新的研究人员参与MR/DD研究，促进与其他mrrc的研究活动，以及提高资助研究项目的质量和生产力，同时展示成本效益。高度优先考虑的是纳入妇女和来自代表性不足的民族/种族群体的个人作为MRRC的科学家，学员和研究项目的参与者。