Shaping the mammalian skull: modeling how species-specific shape of skeletal elements is generated during development and during evolution

塑造哺乳动物头骨：模拟在发育和进化过程中如何生成物种特定形状的骨骼元素

• 批准号: 1905829
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1905829
• 关键词: Shaping; mammalian; skull; modeling; how

Developmental variation is one of the primary pathways of phenotypic diversification of species, but how shape is generated during development remains unresolved. In this project we will quantify the shape of specific bones and cartilages that make up the skull and facial skeleton through development and use mathematical models and morphometrics to try to predict how the unique faces observed in many different species of mammals evolved. The project combines developmental genetics (transgenic mice) with high-density imaging, morphometrics, and modeling and partners a developmental biologist (Prof Abigail Tucker) with a morphometrician and quantitative paleobiologist (Prof Anjali Goswami).

发育变异是物种表型多样化的主要途径之一，但在发育过程中形状是如何产生的仍未解决。在这个项目中，我们将通过发育来量化组成头骨和面部骨骼的特定骨骼和软骨的形状，并使用数学模型和形态计量学来试图预测在许多不同物种的哺乳动物中观察到的独特面孔是如何进化的。该项目将发育遗传学(转基因小鼠)与高密度成像、形态计量学和建模相结合，并与一名发育生物学家(阿比盖尔·塔克教授)和一名形态计量学家和定量古生物学家(安贾利·戈斯瓦米教授)合作。

项目成果

The Intertwined Evolution and Development of Sutures and Cranial Morphology.

• DOI: 10.3389/fcell.2021.653579
• 发表时间: 2021
• 期刊: Frontiers in cell and developmental biology
• 影响因子: 5.5
• 作者: White HE;Goswami A;Tucker AS
• 通讯作者: Tucker AS

A comparison of metrics for quantifying cranial suture complexity.

• DOI: 10.1098/rsif.2020.0476
• 发表时间: 2020-10
• 期刊: Journal of the Royal Society, Interface
• 作者: White HE;Clavel J;Tucker AS;Goswami A
• 通讯作者: Goswami A