Effects of diet on growth hormone-IGF-1 axis

饮食对生长激素-IGF-1轴的影响

• 批准号: 6522660
• 负责人: NORMAN F BOYD
• 金额: $ 22.34万
• 依托单位: ONTARIO CANCER INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-19 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6522660
• 关键词: binding proteins; breast neoplasms; cancer prevention; dietary carbohydrates; dietary lipid; female; hormone related neoplasm /cancer; human subject; insulinlike growth factor; menopause; nutrition aspect of cancer; patient oriented research; postmenopause; somatotropin; women's health

The specific aim of this proposal is to determine whether In premenopausal and postmenopausal women blood levels of Insulin like Growth Factor-I, Insulin like Growth Factor Binding Protein -3 and Growth hormone are influenced by a low-fat high- carbohydrate diet. The general method to be employed will be to perform assays for growth factors and hormone on blood samples, and nutrient analysis of food records, collected from subjects taking part in our ongoing multicentre randomized dietary intervention trial. This trial is designed to test the hypothesis that intervention with a low-fat high-carbohydrate diet will, in women with extensive mammographic densities, over a 10 year period reduce the incidence of breast cancer by 29 percent. The trial is explanatory in that it seeks to determine if there is a biological effect of dietary fat reduction in terms of a reduction in breast cancer incidence. To meet this goal we have selected as participants highly motivated subjects who are at increased risk of breast cancer, we have provided them with a high level of assistance in making a dietary alteration, we follow them carefully to ensure the maintenance of dietary change and the correct identification of subjects who develop breast cancer, and we plan to analyse the results according to study group and dietary compliance. Recruitment of the 4615 subjects required for the trial was completed in November 1998. (A total of 4693 were randomized). Blood samples and food records from subjects enroled in the trial will be used to test the hypotheses given below about the effects of dietary intervention on growth factors and hormones associated with breast cancer risk. Modulation of these factors by dietary intervention would indicate potential mechanisms by which diet may influence risk of breast cancer. Although not the purpose of the research proposed here, the long term nature of the trial, the complete follow-up of all subjects, and the complete ascertainment of breast cancer, will ultimately allow any changes in blood markers found in the present research to be examined in relation to changes in breast cancer incidence.

这项建议的具体目的是确定绝经前和绝经后妇女的胰岛素样生长因子-I、胰岛素样生长因子结合蛋白-3和生长激素水平是否受到低脂肪高碳水化合物饮食的影响。将采用的一般方法将是对血液样本进行生长因子和激素的分析，并对食物记录进行营养分析，这些都是从参与我们正在进行的多中心随机饮食干预试验的受试者收集的。这项试验旨在验证这样一种假设，即在乳房X光检查密度较大的女性中，通过低脂肪、高碳水化合物饮食的干预，可以在10年内将乳腺癌发病率降低29%。这项试验是解释性的，因为它试图确定从降低乳腺癌发病率的角度来看，减少饮食脂肪是否具有生物学效应。为了实现这一目标，我们选择了高积极性的乳腺癌高危受试者作为参与者，我们为他们提供了高水平的饮食改变帮助，我们仔细地跟踪他们，以确保保持饮食改变和正确识别罹患乳腺癌的受试者，我们计划根据研究小组和饮食依从性来分析结果。该试验所需的4615名受试者的招募工作已于1998年11月完成。(共有4693人被随机抽取)。参与试验的受试者的血液样本和食物记录将被用来检验以下关于饮食干预对与乳腺癌风险相关的生长因子和激素的影响的假设。通过饮食干预来调节这些因素将表明饮食可能影响乳腺癌风险的潜在机制。尽管不是这里提出的研究的目的，但试验的长期性质、对所有受试者的完全随访以及对乳腺癌的完全确定，最终将使我们能够检查本研究中发现的血液标志物的任何变化与乳腺癌发病率的变化。