PLASMA LIPIDS AND FAMILIAL BREAST CANCER

拟议研究的长期目标是确定 影响乳腺癌的发病率，并利用这一信息， 研究预防这种疾病的方法。具体来说就是 建议确定血浆脂质和脂蛋白水平是否 如先前的工作所表明的，与乳腺癌的家族风险有关。 拟议研究的目的仅仅是确定 血脂水平与家族史有关 乳腺癌的风险，而不是在这个阶段，以确定是否有任何这样的 联想起源于遗传。据预测，HDL-C将是 升高和TG抑郁的妇女谁是家庭成员在增加 乳腺癌的风险相比，女性成员的家庭谁不是在 增加患病风险。 家庭将从广泛的谱系中选出， 为克赖顿大学的乳腺癌患者编写的。这些 系谱将用于识别2种类型的家庭。其中，在 至少有2名一级亲属患上乳腺癌（称为 家族性乳腺癌）和另一种乳腺癌发生在 至少3代中只有1例女性（称为散发性乳腺癌） 癌症）。患有家族性乳腺癌的家庭将与 根据病例诊断时的年龄确定是否患有散发性乳腺癌。 乳腺癌病例中未受影响的一级女性亲属 然后，将要求被确定的家庭参加一项研究， 对人口、流行病学和营养数据进行测量， 获得用于测量血浆脂质的空腹血液。 不同年龄段的成对家庭（零星家庭和家族家庭）的女性成员 患乳腺癌的风险将与 确定是否有证据表明， 与血脂水平的关系。其他变量的影响 任何发现的关联都将被检查。这些变量 包括体重、营养摄入、酒精摄入、激素 使用和吸烟状态。

The long term goal of the proposed research is to identify factors that influence the incidence of breast cancer and to exploit this information in research into methods of preventing the disease. Specifically, it is proposed to determine whether plasma levels of lipids and lipoproteins are related, as previous work has suggested, to familial risk of breast cancer. The purpose of the proposed study is solely to determine whether a relationship exists between the concentration of plasma lipids and familial risk of breast cancer and not at this stage to determine whether any such association is genetic in origin. It is predicted that HDL-C will be elevated and TG depressed in women who are members of families at increased risk of breast cancer compared to female members of families who are not at increased risk of the disease. Families will be selected from the extensive pedigrees that have been compiled for patients with breast cancer at Creighton University. These pedigrees will be used to identify 2 types of families. One in which at least 2 first degree relatives have developed breast cancer (referred to as familial breast cancer) and another in which breast cancer has occurred in only 1 women in at least 3 generations (referred to as sporadic breast cancer). Families with familial breast cancer will be matched with families with sporadic breast cancer according to the age at diagnosis of the case. The unaffected first degree female relatives of the breast cancer cases in the families so identified will then be asked to participate in a study and measurement made of demographic, epidemiological, and nutritional data and fasting blood obtained for measurement of plasma lipids. Female members of pairs of families (sporadic and familial) at different risks for the development of breast cancer will then be compared to determine whether evidence exists of an association between familial risk of breast cancer and plasma lipid level. The influence of other variables on any association that is found will then be examined. These variables will include body weight nutritional intake, alcohol consumption, hormone use, and smoking status.