CORTICAL PLASTICITY--LEARNING ORIGINS OF HUMAN DISABILITY
皮质可塑性--学习人类残疾的起源
基本信息
- 批准号:6449802
- 负责人:
- 金额:$ 20.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-05-01 至 2002-04-30
- 项目状态:已结题
- 来源:
- 关键词:Aotus behavior test behavioral /social science research tag cerebral cortex chordate locomotion computer data analysis disease /disorder model dystonia electrophysiology experience learning method development motor cortex nervous system disorder neural information processing neural plasticity neuroanatomy psychomotor function sensorimotor system sensory cortex tendon injury
项目摘要
An overall objective of our research is to create a foundation
science for understanding the contributions of cortical plasticity
and learning to the origins of, and the expressions of human
neurological disability, and to use that new understanding to guide
remediation therapies. In this project, we shall study cortical
plastic changes induced by repetitive, stereotyped, cognitively
important movement exercises generating coincident afferent
inputs that degrade the cortical representations of muscle and skin
afferent information in the cortex. We shall further document the
neurology of emergent repetitive strain injuries (RSI) including
focal dystonias of the hand (Fdh) generated by this behavioral
training, and relate training-generated de-differentiation of brain
representations of movements and feedback sensory information
controlling movements to the progression of sensorimotor
dysfunction. We shall define the relationship of experience-
induced changes in SI and MI to the onset and progression of pain
and inflammation in the arm, and determine whether or not pain
onset a) enables or amplifies, or b) could be triggered by dynamic,
parralel cortical representational degradation. We shall determine
whether induced plastic changes in motor and sensory cortical
fields are posturally specific, which is signature feature of emergent
focal dystonias. We shall determine whether or not and how
postural strain might contribute to RSI/FDh genesis. Finally, we
shall evaluate remediation training strategies in this primate model,
to access behavioral strategies for redifferentiating cortical
representations of sensory afferents and movements that have been
degraded by RSI/FDh-inducing behaviors.
This study should lead to a fundamental change in how we view
cortical plasticity and learning contributions to chronic neurological
disease, and could have a major impact on the development of
more effective remediation therapies for this very large and
growing patient group.
我们研究的总体目标是建立一个基础
理解大脑皮层可塑性的科学
学习人类语言的起源和表达
神经系统残疾,并使用新的理解来指导
补救疗法。 在这个项目中,我们将研究
可塑性变化引起的重复,刻板,认知
产生同步传入的重要运动练习
降低肌肉和皮肤的皮质表征的输入
皮层的传入信息 我们将进一步记录
紧急重复性劳损(RSI)的神经病学,包括
由这种行为产生的手部局部肌张力障碍(Fdh)
训练和相关训练产生的大脑去分化
运动和反馈感觉信息的表征
控制运动到感觉运动的进展
功能障碍 我们将定义经验的关系-
引起SI和MI的变化对疼痛的发作和进展
以及手臂上的炎症,并确定是否疼痛
起始a)使能或放大,或B)可以由动态触发,
parralel皮质代表性退化。 我们将决定
是否诱导了运动和感觉皮层的可塑性变化
场域是姿态特定的,这是突现的标志性特征
局部肌张力障碍 我们将决定是否以及如何
姿势性劳损可能是RSI/FDh的发生原因之一。 最后我们
将评估在这个灵长类动物模型中的补救训练策略,
来获取重新分化大脑皮层的行为策略
感觉传入和运动的表征,
通过RSI/FDh诱导行为降解。
这项研究应该导致我们如何看待
皮质可塑性和学习对慢性神经系统疾病的影响
疾病,并可能对发展产生重大影响,
更有效的补救疗法,
不断增长的患者群体。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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MICHAEL M MERZENICH其他文献
MICHAEL M MERZENICH的其他文献
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{{ truncateString('MICHAEL M MERZENICH', 18)}}的其他基金
Models of catastrophic cortical plasticity contributing
灾难性皮质可塑性贡献模型
- 批准号:
6663430 - 财政年份:2002
- 资助金额:
$ 20.73万 - 项目类别:
Models of catastrophic cortical plasticity contributing
灾难性皮质可塑性贡献模型
- 批准号:
6588521 - 财政年份:2002
- 资助金额:
$ 20.73万 - 项目类别:
CORTICAL PLASTICITY--LEARNING ORIGINS OF HUMAN DISABILITY
皮质可塑性--学习人类残疾的起源
- 批准号:
6323425 - 财政年份:2000
- 资助金额:
$ 20.73万 - 项目类别:
CORTICAL PLASTICITY--LEARNING ORIGINS OF HUMAN DISABILITY
皮质可塑性--学习人类残疾的起源
- 批准号:
6314151 - 财政年份:2000
- 资助金额:
$ 20.73万 - 项目类别:
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