CORE--TISSUE PROCUREMENT

该方案项目的组织采购核心设施将提供 为每个调查员提供服务。这将加强每个项目，增加 有效利用时间和资金，并确保 项目。核心将获得人类肿瘤组织并维持一组 冷冻恶性肿瘤、邻近非恶性皮肤、无日晒皮肤 和外周血淋巴细胞。它还将维持实验室 对样本进行编码，以保持患者的机密性并防止 实验偏见。肿瘤细胞系也将保持在核心和 根据需要分发给调查人员。所有的标本都将 经组织学证实。肿瘤的mRNA、DNA和DNA的中央加工 将通过核心设施为所有项目提供蛋白质 允许：1)建立一个安全、集中的基本材料储存库 研究项目S具有准确编码保存记录的能力。2) 多名调查人员有效利用稀缺材料。3) 收集、储存和处理程序的标准化，确保 由不同研究人员获得的材料的一致性。4)一个 高效的跟踪、交付和处理系统，可进行调整和满足 计划项目的组织要求。

The Tissue Procurement Core Facility for t his Program Project will provide services to each investigator. This will enhance each project, increase the efficient use of time and funds, and ensure coordination between projects. The Core will obtain human tumor tissue and maintain a bank of frozen malignant tumors, adjacent non-malignant skin, non-sun exposed skin and peripheral blood lymphocytes. It will also maintain laboratory specimen coding to maintain patient confidentiality and prevent experimental bias. Tumor cell line will also be maintained in the Core and distributed amongst investigators as required. All specimens will be histologically verified. Central processing of tumors for mRNA, DNA, and protein will be provided for all projects through the Core facility allowing: 1) a safe, central repository of essential materials for the research project s with accurate coded record keeping capabilities. 2) efficient utilization of scarce materials by multiple investigators. 3) standardization of collection, storage, and processing procedures, ensuring uniformity of materials obtained by different investigators. 4) An efficient tracking, delivery, and processing system that adjusts and meets the tissue requirements for the program project.