Retroviral Co-Infections: HIV, HTLV and Drug Abuse

描述：（由申请人提供）这是申请号1的修订版 R01 A149744-01。人嗜T淋巴细胞病毒1型和2型（HTLV-I， HTLV-II）共感染5- 10%的HIV感染个体，特别是在 静脉注射吸毒是一种获取方式的大都市地区。 来自人类研究和非人灵长类动物比较研究的证据 表明HIV/HTLV合并感染的复合效应增加 HTLV-I/II病毒复制和病毒负荷。这可能会加速风险， 神经退行性疾病、淋巴增生综合征和其他 HTLV相关疾病。在这个项目中，病毒学，血液学，临床 与HIV/HTLV合并感染相关的特征和药物滥用模式 将被定性。诊所人口将包括250多名合并感染者 新奥尔良艾滋病门诊的病人。我们的患者队列就是其中之一 是美国最大的我们将确定 艾滋病毒和HTLV-I/II病毒负担和（1）过去和现在的非法 药物使用，（2）疾病的临床和神经系统表现，（3） CD 4和CD 8下降，（4）AIDS的发展和（5）HTLV-I/II的表达 - 双重感染患者的相关疾病。将进行比较 有超过2,500名患者仅感染了HIV-1， 成人疾病谱临床数据库现有临床 标本库中可用的标本和新鲜获得的血液 标本将用于确定HTLV-I/II病毒之间的关系 在外周血单个核细胞中的表达和临床表达 疾病该项目的最终目标是定义 HIV/HTLV合并感染是疾病分期和设计的必要步骤 适当的治疗。

DESCRIPTION: (provided by applicant) This is a revision of application number 1 R01 A149744-01. The human T lymphotropic viruses types 1 and 2 (HTLV-I, HTLV-II) co-infect 5-1 0 percent of HIV-infected individuals, especially in metropolitan areas where intravenous drug use is a mode of acquisition. Evidence from human studies and from comparative studies in nonhuman primates suggests that the composite effect of HIV/HTLV co-infection is increased HTLV-I/II viral replication and viral burden. This may accelerate the risk for neurodegenerative disease, lymphoproliferative syndromes and other HTLV-associated diseases. In this project the virologic, hematologic, clinical features and substance abuse patterns associated with HIV/HTLV co-infections will be characterized. The clinic population will include over 250 co-infected individuals at the New Orleans HIV Outpatient Clinic. Our patient cohort is one of the largest in the United States. We will determine the relationship between HIV and HTLV-I/II viral burden and (1) past and present patterns of illicit drug use, (2) clinical and neurologic manifestations of disease, (3) rates of CD4 and CD8 decline, (4) development of AIDS and (5) expression HTLV-I/II -associated illnesses in dually infected patients. Comparisons will be made with over 2,500 patients infected with HIV-1 alone, using information extracted from the Adult Spectrum of Disease Clinical Database. Existing clinical specimens available in a specimen repository and freshly obtained blood specimens will be used to determine the relationship between HTLV-I/II virus expression in peripheral blood mononuclear cells and expression of clinical disease. The ultimate goal of this project is to define the dynamics of HIV/HTLV co-infections as a necessary step in disease staging and devising appropriate treatments.