Retroviral Co-Infections: HIV, HTLV and Drug Abuse

描述：(申请人提供)这是第1号申请的修订版 R01 A149744-01。人类嗜T淋巴细胞病毒1型和2型(HTLV-I， HTLV-II)共感染5%-10%的艾滋病毒感染者，特别是在 在大都市地区，静脉注射毒品是一种获取方式。 来自人类研究和非人类灵长类动物比较研究的证据 提示HIV/HTLV混合感染的综合效应增加 HTLV-I/II病毒复制和病毒负担。这可能会加速 神经退行性疾病、淋巴增生性综合征和其他 HTLV相关疾病。在这个项目中，病毒学、血液学、临床 与HIV/HTLV混合感染相关的特征和药物滥用模式 将被描述为。诊所人群将包括250多名共同感染的患者。 新奥尔良艾滋病门诊的患者。我们的患者队列是其中之一 是美国最大的。我们将确定两国之间的关系 艾滋病毒和HTLV-I/II病毒负担和(1)过去和现在的非法模式 药物使用，(2)疾病的临床和神经学表现，(3) (4)艾滋病的发生和(5)HTLV-I/II的表达 -双重感染患者的相关疾病。我们将进行比较 使用提取的信息，仅感染HIV-1的患者就超过2500人 摘自成人疾病谱临床数据库。现有临床 标本储存库中可获得的标本和新获得的血液 标本将用于确定HTLV-I/II病毒之间的关系 外周血单个核细胞的表达及临床意义 疾病。该项目的最终目标是定义 HIV/HTLV混合感染是疾病分期和设计的必要步骤 适当的治疗。

DESCRIPTION: (provided by applicant) This is a revision of application number 1 R01 A149744-01. The human T lymphotropic viruses types 1 and 2 (HTLV-I, HTLV-II) co-infect 5-1 0 percent of HIV-infected individuals, especially in metropolitan areas where intravenous drug use is a mode of acquisition. Evidence from human studies and from comparative studies in nonhuman primates suggests that the composite effect of HIV/HTLV co-infection is increased HTLV-I/II viral replication and viral burden. This may accelerate the risk for neurodegenerative disease, lymphoproliferative syndromes and other HTLV-associated diseases. In this project the virologic, hematologic, clinical features and substance abuse patterns associated with HIV/HTLV co-infections will be characterized. The clinic population will include over 250 co-infected individuals at the New Orleans HIV Outpatient Clinic. Our patient cohort is one of the largest in the United States. We will determine the relationship between HIV and HTLV-I/II viral burden and (1) past and present patterns of illicit drug use, (2) clinical and neurologic manifestations of disease, (3) rates of CD4 and CD8 decline, (4) development of AIDS and (5) expression HTLV-I/II -associated illnesses in dually infected patients. Comparisons will be made with over 2,500 patients infected with HIV-1 alone, using information extracted from the Adult Spectrum of Disease Clinical Database. Existing clinical specimens available in a specimen repository and freshly obtained blood specimens will be used to determine the relationship between HTLV-I/II virus expression in peripheral blood mononuclear cells and expression of clinical disease. The ultimate goal of this project is to define the dynamics of HIV/HTLV co-infections as a necessary step in disease staging and devising appropriate treatments.