Retroviral Co-Infections: HIV, HTLV and Drug Abuse

逆转录病毒合并感染：HIV、HTLV 和药物滥用

• 批准号: 6608060
• 负责人: MARK A BEILKE
• 金额: $ 35.91万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6608060
• 关键词: AIDS /HIV neuropathy; CD antigens; MHC class II antigen; cytotoxic T lymphocyte; disease /disorder proneness /risk; drug abuse; epidemiology; helper T lymphocyte; human T cell lymphotropic virus type 1; human T cell lymphotropic virus type 2; human data; human tissue; interleukin 2; lymphocyte proliferation; pathologic process; patient oriented research; polymerase chain reaction; virus antigen; virus load; virus replication

DESCRIPTION: (provided by applicant) This is a revision of application number 1 R01 A149744-01. The human T lymphotropic viruses types 1 and 2 (HTLV-I, HTLV-II) co-infect 5-1 0 percent of HIV-infected individuals, especially in metropolitan areas where intravenous drug use is a mode of acquisition. Evidence from human studies and from comparative studies in nonhuman primates suggests that the composite effect of HIV/HTLV co-infection is increased HTLV-I/II viral replication and viral burden. This may accelerate the risk for neurodegenerative disease, lymphoproliferative syndromes and other HTLV-associated diseases. In this project the virologic, hematologic, clinical features and substance abuse patterns associated with HIV/HTLV co-infections will be characterized. The clinic population will include over 250 co-infected individuals at the New Orleans HIV Outpatient Clinic. Our patient cohort is one of the largest in the United States. We will determine the relationship between HIV and HTLV-I/II viral burden and (1) past and present patterns of illicit drug use, (2) clinical and neurologic manifestations of disease, (3) rates of CD4 and CD8 decline, (4) development of AIDS and (5) expression HTLV-I/II -associated illnesses in dually infected patients. Comparisons will be made with over 2,500 patients infected with HIV-1 alone, using information extracted from the Adult Spectrum of Disease Clinical Database. Existing clinical specimens available in a specimen repository and freshly obtained blood specimens will be used to determine the relationship between HTLV-I/II virus expression in peripheral blood mononuclear cells and expression of clinical disease. The ultimate goal of this project is to define the dynamics of HIV/HTLV co-infections as a necessary step in disease staging and devising appropriate treatments.

描述：（由申请人提供）这是对 1 号申请的修订 R01 A149744-01。人类 T 淋巴细胞病毒 1 型和 2 型（HTLV-I， HTLV-II) 共同感染 5-1 0% 的 HIV 感染者，尤其是在 在大都市地区，静脉注射毒品是一种获取方式。 来自人类研究和非人类灵长类动物比较研究的证据 表明 HIV/HTLV 合并感染的复合效应增强 HTLV-I/II 病毒复制和病毒负荷。这可能会加速风险 神经退行性疾病、淋巴增殖综合征等 HTLV 相关疾病。在这个项目中，病毒学、血液学、临床 与 HIV/HTLV 合并感染相关的特征和药物滥用模式 将被表征。诊所人口将包括超过 250 名共同感染者 新奥尔良艾滋病毒门诊的个人。我们的患者队列是其中之一 美国最大的。我们将确定之间的关系 HIV 和 HTLV-I/II 病毒负荷以及 (1) 过去和现在的非法模式 药物使用，(2) 疾病的临床和神经系统表现，(3) 发病率 CD4 和 CD8 下降，(4) 艾滋病的发展和 (5) HTLV-I/II 的表达 双重感染患者的相关疾病。将会进行比较 使用提取的信息对 2,500 多名仅感染 HIV-1 的患者进行了研究 来自成人疾病谱临床数据库。现有临床 样本库中提供的样本和新鲜采集的血液 标本将用于确定 HTLV-I/II 病毒之间的关系 外周血单个核细胞中的表达及临床表达 疾病。该项目的最终目标是定义 HIV/HTLV 合并感染是疾病分期和设计的必要步骤 适当的治疗。