THE GLIDING MOTILITY AND CELL INVASION BY PLASMODIUM

疟原虫的滑翔运动和细胞侵袭

• 批准号: 6358730
• 负责人: Victor Nussenzweig
• 金额: $ 38.29万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6358730
• 关键词: Culicidae; Plasmodium; cell adhesion molecules; cell motility; cytoskeletal proteins; gene targeting; genetic library; host organism interaction; mutant; myosins; parasitism; proteomics; thrombospondins; yeast two hybrid system

DESCRIPTION (provided by applicant): Apicomplexa do not have cilia or flagella but glide rapidly on solid substrates. The molecular mechanism of this unique type of motility is obscure. We have provided genetic evidence that TRAP (thrombospondin-related anonymous protein), a typel trans-membrane molecule that bears two adhesive domains, is required both for motility and cell invasion of Plasmodium sporozoites. It has been suggested that gliding and cell invasion is driven by an actin/myosin motor located beneath the plasma membrane of the parasites. The overall objective of this proposal is to identify the motor components, some of which must be directly or indirectly connected to the cytoplasmic tail of TRAP.

描述（由申请人提供）：顶复门没有纤毛或鞭毛 但在固体基质上快速滑动。这种独特的分子机制 运动类型不明确。我们已经提供了遗传证据， （血小板反应蛋白相关的无名蛋白），一种典型的跨膜分子 具有两个粘附结构域，是运动和细胞生长所必需的。 疟原虫子孢子的入侵。有人认为，滑翔和细胞 侵入是由位于质膜下的肌动蛋白/肌球蛋白马达驱动的 的寄生虫。本建议的总体目标是确定 电动机组件，其中一些必须直接或间接连接到 TRAP的胞质尾区。