Minimally Invasive Image-guided Ablation - MINIMA

微创图像引导消融 - MINIMA

• 批准号: 1921546
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1921546
• 关键词: Minimally; Invasive; Image; guided; Ablation

Aims and ObjectivesThe aim of this project is to improve diagnosis and therapy for patients with cancer, combining imaging with minimally invasive treatment. A Magnetic Resonance Imaging (MRI) system will be the sole platform used for moving a magnetic particle to a tumour site within the body and heating the particle, leading to cell death in the surrounding tumour tissue. Using an MRI system allows the region of interest to be imaged with each step, as a new form of image-guided therapy. The main objective of the MRes project will be to reduce the artefacts observed in the acquired images, which are a result of the high susceptibility of the magnetic particle.BackgroundMagnetic Resonance Targeting (MRT) uses the gradient coils within an MRI system to generate magnetic field gradients and move particles to targeted sites within the body. Once at the site of interest, the intention is to destroy tumour cells via heating of the particles. Previous work has shown the feasibility of MRT, by manipulating cells labelled with magnetic nanoparticles. This project will develop this idea by using a single steel ball, instead of nanoparticles. A disadvantage to the increased particle size is the susceptibility artefacts which are observed in the acquired image. The high susceptibility of the iron within the steel ball distorts the magnetic field in the local vicinity, leading to increased T2* dephasing and loss of signal. Decreasing the size of the artefact will improve the localization of the steel ball and allow more precise location and movement of the particle through the tissue. Some research has been carried out to overcome these artefacts, for a steel ball in a swine artery. For the MRes project I will investigate the use of different pulse sequences and the effect of changing pulse sequence parameters, on the acquired images.

目的和目标该项目的目的是将影像学与微创治疗相结合，改善癌症患者的诊断和治疗。磁共振成像（MRI）系统将是用于将磁性粒子移动到体内肿瘤部位并加热粒子，导致周围肿瘤组织细胞死亡的唯一平台。使用 MRI 系统可以在每一步中对感兴趣区域进行成像，作为一种新形式的图像引导治疗。 MRes 项目的主要目标是减少在采集的图像中观察到的伪影，这些伪影是由磁性粒子的高敏感性造成的。背景磁共振靶向 (MRT) 使用 MRI 系统内的梯度线圈来生成磁场梯度，并将粒子移动到体内的目标部位。一旦到达感兴趣的部位，目的是通过加热颗粒来破坏肿瘤细胞。之前的工作已经通过操纵磁性纳米颗粒标记的细胞展示了 MRT 的可行性。 该项目将通过使用单个钢球而不是纳米颗粒来发展这一想法。增加颗粒尺寸的缺点是在采集的图像中观察到的磁化率伪影。钢球内铁的高磁化率会扭曲局部附近的磁场，导致 T2* 相移增加和信号丢失。减小人工制品的尺寸将改善钢球的定位，并允许颗粒在组织中更精确的定位和运动。已经进行了一些研究来克服这些人工制品，例如猪动脉中的钢球。对于 MRes 项目，我将研究不同脉冲序列的使用以及改变脉冲序列参数对采集图像的影响。

项目成果

Scalable magnet geometries enhance tumour targeting of magnetic nano-carriers

• DOI: 10.1016/j.matdes.2020.108610
• 发表时间: 2020-06-01
• 期刊: MATERIALS & DESIGN
• 影响因子: 8.4
• 作者: Mohseni, Matin;Connell, John J.;Lythgoe, Mark F.
• 通讯作者: Lythgoe, Mark F.

Image-Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System.

• DOI: 10.1002/advs.202105333
• 发表时间: 2022-04
• 期刊: ADVANCED SCIENCE
• 影响因子: 15.1
• 作者: Baker, Rebecca R.;Payne, Christopher;Yu, Yichao;Mohseni, Matin;Connell, John J.;Lin, Fangyu;Harrison, Ian F.;Southern, Paul;Rudrapatna, Umesh S.;Stuckey, Daniel J.;Kalber, Tammy L.;Siow, Bernard;Thorne, Lewis;Punwani, Shonit;Jones, Derek K.;Emberton, Mark;Pankhurst, Quentin A.;Lythgoe, Mark F.
• 通讯作者: Lythgoe, Mark F.