Modelling critical parameters for drug discovery via intramuscular injection

医疗保健技术的最新创新旨在提高以患者为中心的肠内给药。临床技术可以提高依从性，同时改善患者护理和生活质量，包括长效注射剂和无痛皮内给药装置。随着GSK长期作用注射项目的增加，在早期阶段建立这种配方模型的能力将是缩短开发时间、降低成本、减少动物使用和更好地了解临床表现的重要一步。在动物研究之前，我们在评估长效注射制剂的释放率方面有很大的差距。巴斯大学的Mrsny教授开发了一种体外溶解仪器，专门用于模拟皮下空间的“立即释放”注射的生理条件。该项目的目的是修改仪器，以更好地模拟皮下和肌肉注射的ling作用注射的关键方面。

Recent innovations in healthcare technology aim to improve the patient centricity of perenteral drug delivery. Clinical technologies that can deliver improved compliance while improving patient care and quality of life, include long acting injectables and pain free intradermal delivery devices.With the growing number of long acting injection programs at GSK, the ability to model such formulations at an early stage will be an important step towards shortening development timelines, reducing costs, reducing animal usage, and gaining an overall better understanding of clinical performance. We have significant gap in our ability to assess the release rates of long acting injectable formulations prior to animal studies. An in vitro dissolution instrument specially designed to simulate physiological conditions of subcutaneous space for "immediate release" injectables has been developed by Professor Mrsny at University of Bath. The objective of this project will be to modify the instrument to better model critical aspects of ling acting injections administered both subcutaneously and intramuscularly.