Modelling critical parameters for drug discovery via intramuscular injection

通过肌肉注射对药物发现的关键参数进行建模

• 批准号: 1924060
• 金额: --
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1924060
• 关键词: Modelling; critical; parameters; drug; discovery

Recent innovations in healthcare technology aim to improve the patient centricity of perenteral drug delivery. Clinical technologies that can deliver improved compliance while improving patient care and quality of life, include long acting injectables and pain free intradermal delivery devices.With the growing number of long acting injection programs at GSK, the ability to model such formulations at an early stage will be an important step towards shortening development timelines, reducing costs, reducing animal usage, and gaining an overall better understanding of clinical performance. We have significant gap in our ability to assess the release rates of long acting injectable formulations prior to animal studies. An in vitro dissolution instrument specially designed to simulate physiological conditions of subcutaneous space for "immediate release" injectables has been developed by Professor Mrsny at University of Bath. The objective of this project will be to modify the instrument to better model critical aspects of ling acting injections administered both subcutaneously and intramuscularly.

医疗保健技术的最新创新旨在提高经肠给药的患者中心性。临床技术可以提供更好的依从性，同时改善患者护理和生活质量，包括长效注射剂和无痛皮内给药装置。随着GSK长效注射项目的不断增加，在早期阶段建立此类制剂模型的能力将是缩短开发时间表，降低成本，减少动物使用，并全面更好地了解临床性能。我们在动物研究之前评估长效注射制剂释放速率的能力存在显著差距。巴斯大学的Mrsny教授开发了一种专门设计用于模拟皮下空间生理条件的“速释”注射剂体外溶出仪。本项目的目的是修改仪器，以更好地模拟皮下和肌内注射给药的长效注射剂的关键方面。