Modeling critical parameters of the intramuscular injection site

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Novel parenteral delivery technologies including long acting injection depots and intradermal devices have becomeincreasingly important to formulation strategies to optimize drug efficacy while minimizing injection frequency. Atpresent, in vitro tools fail to accurately model in vivo performance for these various parenteral routes, particularly forintra-muscular (IM) injections. Such bio-predictive tools would help guide scientists towards optimal formulationpreparation and would help reduce reliance on preclinical in vivo data which is costly to generate, delays the productdevelopment cycle, and too often, is not predictive of clinical results. Studies in the laboratory of Professor Mrsny atthe University of Bath have led to the development of a novel method (Scissor) to simulate physiological dynamics ofthe hypodermis, the site of subcutaneous injections. GSK has funded a PhD studentship for me, Adam McCartan, tosupport the identification of parameters that control drug fate at an IM injection site with the goal of setting up a toolsimilar to the Scissor system. I will receive multi-disciplinary training in a highly-applied environment, and be activelyinvolved in knowledge transfer between the University of Bath and GSK.