课题基金 / 基金详情

THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT

THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
胃酸泵作为溃疡治疗的目标
批准号：
6524310
负责人：
George Sachs
金额：
$24.95万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-09-15 至 2005-08-31
来源：
https://reporter.nih.gov/project-details/6524310
关键词：
antiulcer drug benzimidazole analog binding sites chemical models enzyme inhibitors enzyme mechanism enzyme structure gastric acid hydrogen potassium exchanging ATPase hydrogen transport molecular dynamics pharmacokinetics

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英文摘要
This is a new application from an established investigator to investigate structure function relationships of the H+,K+ ATPase. This PI proposes to investigate a new class of acid suppressant medication, imidazo-1,2alpha-pyridnes, which are non-covalent inhibitors of the enzyme. The potential binding sites of SCH28080 and other imidazo-pyridines will be investigated by kinetic measurements in cells transfected with the H+,K+ ATPase and mutated enzyme. Specific membrane segments involved in recognition of this class of inhibitors will be identified. Models will largely rely on the recently identified crystal structure of sr Ca ATPase and Neurospora H+ ATPases, thus the current proposal will refine the model that currently is proposed and maybe used to generate structure-function data for understanding the ion transport role of H+,K+ ATPase and its regulation by this new class of acid suppressant drugs.
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