The Gastric Acid Pump as a Target for Ulcer Treatment

胃酸泵作为溃疡治疗的目标

• 批准号: 8089769
• 负责人: George Sachs
• 金额: $ 22.87万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089769
• 关键词: ATP phosphohydrolase; Acidity; Acids; Address; Antibiotics; Apical; Area; Binding; Binding Sites; Biotinylation; Carcinogens; Cell membrane; Cells; Chimeric Proteins; Choices and Control; Computer Simulation; Confocal Microscopy; Development; Disease; Docking; Dose; Failure; Future; Gastric Acid; Gastric Acid Secretion Inhibition; Gastric Parietal Cells; Gastroesophageal reflux disease; Growth; H(+)-K(+)-Exchanging ATPase; Half-Life; Healed; Helicobacter pylori; Homology Modeling; Hour; Immunoprecipitation; Ion Exchange; Ion Transport; Ions; Kinetics; Knock-in Mouse; Knowledge; Label; Libraries; Life; Link; Maintenance; Medical; Membrane; Membrane Proteins; Methods; Microscopy; Modeling; Molecular; Mutation; Na(+)-K(+)-Exchanging ATPase; Omeprazole; Ouabain; Pathway interactions; Patients; Persistent pain; Pharmaceutical Preparations; Plasma; Precipitation; Prodrugs; Property; Proteins; Proton Pump Inhibitors; Pump; RNA Interference; Regulation; Resistance; Resolution; Rest; Role; Scaffolding Protein; Site; Site-Directed Mutagenesis; Small Interfering RNA; Sorting - Cell Movement; Speed; Stomach; Structure; Surface; Symptoms; Time; Transgenic Mice; Ubiquitin; Ulcer; Uncertainty; Vesicle; analog; apical membrane; base; cellular microvillus; design; falls; glycation; healing; improved; in vivo; inhibitor/antagonist; innovation; insight; kidney cell; molecular dynamics; mouse model; novel; novel strategies; protein transport; public health relevance; residence; success; three dimensional structure; tool; trafficking; transport inhibitor