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The Gastric Acid Pump as a Target for Ulcer Treatment

The Gastric Acid Pump as a Target for Ulcer Treatment
胃酸泵作为溃疡治疗的目标
批准号：
8089769
负责人：
George Sachs
金额：
$22.87万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-08-01 至 2011-07-31
来源：
https://reporter.nih.gov/project-details/8089769
关键词：
ATP phosphohydrolaseAcidityAcidsAddressAntibioticsApicalAreaBindingBinding SitesBiotinylationCarcinogensCell membraneCellsChimeric ProteinsChoices and ControlComputer SimulationConfocal MicroscopyDevelopmentDiseaseDockingDoseFailureFutureGastric AcidGastric Acid Secretion InhibitionGastric Parietal CellsGastroesophageal reflux diseaseGrowthH(+)-K(+)-Exchanging ATPaseHalf-LifeHealedHelicobacter pyloriHomology ModelingHourImmunoprecipitationIon ExchangeIon TransportIonsKineticsKnock-in MouseKnowledgeLabelLibrariesLifeLinkMaintenanceMedicalMembraneMembrane ProteinsMethodsMicroscopyModelingMolecularMutationNa(+)-K(+)-Exchanging ATPaseOmeprazoleOuabainPathway interactionsPatientsPersistent painPharmaceutical PreparationsPlasmaPrecipitationProdrugsPropertyProteinsProton Pump InhibitorsPumpRNA InterferenceRegulationResistanceResolutionRestRoleScaffolding ProteinSiteSite-Directed MutagenesisSmall Interfering RNASorting - Cell MovementSpeedStomachStructureSurfaceSymptomsTimeTransgenic MiceUbiquitinUlcerUncertaintyVesicleanalogapical membranebasecellular microvillusdesignfallsglycationhealingimprovedin vivoinhibitor/antagonistinnovationinsightkidney cellmolecular dynamicsmouse modelnovelnovel strategiesprotein transportpublic health relevanceresidencesuccessthree dimensional structuretooltraffickingtransport inhibitor

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