NOVEL NEURONAL SIGNALING MODULE
NOVEL NEURONAL SIGNALING MODULE
批准号:
6540235
负责人:
MITCHELL GOLDFARB
金额:
$39.5万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-08-01 至 2003-12-31
中文摘要
描述(来自申请人摘要):神经系统发育和
功能是由神经元对广泛的
细胞外分子刺激这些刺激影响神经细胞
存活,分化,轴突导向,突触形成,突触
可塑性和神经生理反应通过一系列的信号
转导机制仍然知之甚少。我的实验室
在神经元细胞中发现了一种新的信号模块,
新发现的蛋白激酶支架蛋白,一种蛋白激酶级联,
以及一组以前被认为在细胞外起生长作用的蛋白质
因素本申请中提出的实验预期
鉴定通过这种新激酶模块发信号的细胞外刺激,
以确定这种信号通路的神经生物学后果。在
除了定义一个新的
生物化学途径,这些研究可能会显着改善我们的
了解神经元发育和功能的机制。
英文摘要
DESCRIPTION (From the applicant's abstract): Nervous system development and
function are regulated by neuronal responses to an extensive repertoire of
extracellular molecular stimuli. These stimuli influence neuronal cell
survival, differentiation, axonal guidance, synapse formation, synaptic
plasticity, and neurophysiological responses through an array of signal
transduction mechanisms which are still poorly understood. My laboratory has
uncovered a novel signaling module within neuronal cells that consists of a
newly discovered protein kinase scaffold protein, a cascade of protein kinases,
and a set of proteins previously thought to function extracellularly as growth
factors. The experiments proposed within this application are expected to
identify extracellular stimuli that signal through this novel kinase module and
to determine the neurobiological consequences of this signaling pathway. In
addition to the importance of defining the architecture and regulation of a new
biochemical pathway, these studies are likely to significantly improve our
understanding of mechanisms underlying neuronal development and function.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
VGSC Modulation by FHFs: Neural Functions and Mechanisms
-
批准号:8161945
-
项目类别:
-
资助金额:$28.06万
-
财政年份:2011
-
负责人:MITCHELL GOLDFARB
-
依托单位:
VGSC Modulation by FHFs: Neural Functions and Mechanisms
-
批准号:8323375
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项目类别:
-
资助金额:$27.86万
-
财政年份:2011
-
负责人:MITCHELL GOLDFARB
-
依托单位:
VGSC Modulation by FHFs: Neural Functions and Mechanisms
-
批准号:8664408
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项目类别:
-
资助金额:$23.26万
-
财政年份:2011
-
负责人:MITCHELL GOLDFARB
-
依托单位:
VGSC Modulation by FHFs: Neural Functions and Mechanisms
-
批准号:8477217
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项目类别:
-
资助金额:$26.89万
-
财政年份:2011
-
负责人:MITCHELL GOLDFARB
-
依托单位:
SNRP at Hunter College
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批准号:7349988
-
项目类别:
-
资助金额:$21.27万
-
财政年份:2006
-
负责人:MITCHELL GOLDFARB
-
依托单位:
NEURONAL FUNCTIONS OF FHFS
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批准号:6836444
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项目类别:
-
资助金额:$37.98万
-
财政年份:2000
-
负责人:MITCHELL GOLDFARB
-
依托单位:
NOVEL NEURONAL SIGNALING MODULE
-
批准号:6394346
-
项目类别:
-
资助金额:$41.58万
-
财政年份:2000
-
负责人:MITCHELL GOLDFARB
-
依托单位:
NOVEL NEURONAL SIGNALING MODULE
-
批准号:6087289
-
项目类别:
-
资助金额:$34.6万
-
财政年份:2000
-
负责人:MITCHELL GOLDFARB
-
依托单位:
NEURONAL FUNCTIONS OF FHFS
-
批准号:6737405
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项目类别:
-
资助金额:$40.13万
-
财政年份:2000
-
负责人:MITCHELL GOLDFARB
-
依托单位:
NEURONAL FUNCTIONS OF FHFS
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批准号:7194356
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项目类别:
-
资助金额:$38.2万
-
财政年份:2000
-
负责人:MITCHELL GOLDFARB
-
依托单位:
NEURONAL FUNCTIONS OF FHFS
-
批准号:6993669
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项目类别:
-
资助金额:$38.2万
-
财政年份:2000
-
负责人:MITCHELL GOLDFARB
-
依托单位:
SNTS--DEVELOPMENTAL FUNCTIONS AND RECEPTOR INTERACTIONS
-
批准号:6182199
-
项目类别:
-
资助金额:$35.27万
-
财政年份:1999
-
负责人:MITCHELL GOLDFARB
-
依托单位:
SNTS--DEVELOPMENTAL FUNCTIONS AND RECEPTOR INTERACTIONS
-
批准号:2836776
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项目类别:
-
资助金额:$33.47万
-
财政年份:1999
-
负责人:MITCHELL GOLDFARB
-
依托单位:
SNTS--DEVELOPMENTAL FUNCTIONS AND RECEPTOR INTERACTIONS
-
批准号:6386496
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项目类别:
-
资助金额:$36.2万
-
财政年份:1999
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负责人:MITCHELL GOLDFARB
-
依托单位:
Role of Myelin in Spinal Cord Regeneration
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批准号:8447511
-
项目类别:
-
资助金额:$33.16万
-
财政年份:1999
-
负责人:MITCHELL GOLDFARB
-
依托单位:
SNTS--DEVELOPMENTAL FUNCTIONS AND RECEPTOR INTERACTIONS
-
批准号:6520039
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项目类别:
-
资助金额:$37.15万
-
财政年份:1999
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负责人:MITCHELL GOLDFARB
-
依托单位:
NOVEL MECHANISMS OF FGF RECEPTOR SIGNALING
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批准号:2701822
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项目类别:
-
资助金额:$7.02万
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财政年份:1997
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负责人:MITCHELL GOLDFARB
-
依托单位:
NOVEL MECHANISMS OF FGF RECEPTOR SIGNALING
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批准号:2502587
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项目类别:
-
资助金额:$6.8万
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财政年份:1997
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负责人:MITCHELL GOLDFARB
-
依托单位:
GENETIC ANALYSIS OF FGF-5 PROTO-ONCOGENE FUNCTION
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批准号:3328779
-
项目类别:
-
资助金额:$19.13万
-
财政年份:1990
-
负责人:MITCHELL GOLDFARB
-
依托单位:
GENETIC ANALYSIS OF FGF-5 PROTO-ONCOGENE FUNCTION
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批准号:3328778
-
项目类别:
-
资助金额:$22.51万
-
财政年份:1990
-
负责人:MITCHELL GOLDFARB
-
依托单位:
海外基金