NOVEL NEURONAL SIGNALING MODULE

描述(摘自申请者摘要)：神经系统发育和 功能是由神经元对一系列广泛的 细胞外分子刺激。这些刺激影响神经细胞 生存、分化、轴突引导、突触形成、突触 通过一系列信号的可塑性和神经生理学反应 转导机制仍然知之甚少。我的实验室有 在神经细胞中发现了一个新的信号模块，它由一个 新发现的蛋白激酶支架蛋白，一系列蛋白激酶， 以及一组以前被认为在细胞外发挥生长作用的蛋白质 各种因素。本申请中提出的实验预计将 识别通过这个新的激酶模块发出信号的细胞外刺激 以确定这一信号通路的神经生物学后果。在……里面 除了定义新的 生物化学途径，这些研究可能会显著改善我们的 了解神经元发育和功能的潜在机制。

DESCRIPTION (From the applicant's abstract): Nervous system development and function are regulated by neuronal responses to an extensive repertoire of extracellular molecular stimuli. These stimuli influence neuronal cell survival, differentiation, axonal guidance, synapse formation, synaptic plasticity, and neurophysiological responses through an array of signal transduction mechanisms which are still poorly understood. My laboratory has uncovered a novel signaling module within neuronal cells that consists of a newly discovered protein kinase scaffold protein, a cascade of protein kinases, and a set of proteins previously thought to function extracellularly as growth factors. The experiments proposed within this application are expected to identify extracellular stimuli that signal through this novel kinase module and to determine the neurobiological consequences of this signaling pathway. In addition to the importance of defining the architecture and regulation of a new biochemical pathway, these studies are likely to significantly improve our understanding of mechanisms underlying neuronal development and function.