NOVEL NEURONAL SIGNALING MODULE

描述（来自申请人摘要）：神经系统发育和 功能是由神经元对广泛的 细胞外分子刺激这些刺激影响神经细胞 存活，分化，轴突导向，突触形成，突触 可塑性和神经生理反应通过一系列的信号 转导机制仍然知之甚少。我的实验室 在神经元细胞中发现了一种新的信号模块， 新发现的蛋白激酶支架蛋白，一种蛋白激酶级联， 以及一组以前被认为在细胞外起生长作用的蛋白质 因素本申请中提出的实验预期 鉴定通过这种新激酶模块发信号的细胞外刺激， 以确定这种信号通路的神经生物学后果。在 除了定义一个新的 生物化学途径，这些研究可能会显着改善我们的 了解神经元发育和功能的机制。

DESCRIPTION (From the applicant's abstract): Nervous system development and function are regulated by neuronal responses to an extensive repertoire of extracellular molecular stimuli. These stimuli influence neuronal cell survival, differentiation, axonal guidance, synapse formation, synaptic plasticity, and neurophysiological responses through an array of signal transduction mechanisms which are still poorly understood. My laboratory has uncovered a novel signaling module within neuronal cells that consists of a newly discovered protein kinase scaffold protein, a cascade of protein kinases, and a set of proteins previously thought to function extracellularly as growth factors. The experiments proposed within this application are expected to identify extracellular stimuli that signal through this novel kinase module and to determine the neurobiological consequences of this signaling pathway. In addition to the importance of defining the architecture and regulation of a new biochemical pathway, these studies are likely to significantly improve our understanding of mechanisms underlying neuronal development and function.